A 3-O-sulfated heparan sulfate dodecasaccharide (12-mer) suppresses thromboinflammation and attenuates early organ injury following trauma and hemorrhagic shock

INTRODUCTION: Dysregulated inflammation and coagulation are underlying mechanisms driving organ injury after trauma and hemorrhagic shock. Heparan sulfates, cell surface glycosaminoglycans abundantly expressed on the endothelial surface, regulate a variety of cellular processes. Endothelial heparan...

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Detalles Bibliográficos
Autores principales: Vidaurre, Maria del Pilar Huby, Osborn, Baron K., Lowak, Kaylie D., McDonald, Michelle M., Wang, Yao-Wei W., Pa, Veda, Richter, Jillian R., Xu, Yongmei, Arnold, Katelyn, Liu, Jian, Cardenas, Jessica C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140401/
https://www.ncbi.nlm.nih.gov/pubmed/37122735
http://dx.doi.org/10.3389/fimmu.2023.1158457

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