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Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan
BACKGROUND: The characteristics and risk factors of post-COVID-19 condition affecting health-related quality of life and the symptom burden are unclear. METHODS: The present, cross-sectional study used the JASTIS (Japan Society and New Tobacco Internet Survey) database. EQ-5D-5L and Somatic Symptom...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Southern Society for Clinical Investigation. Published by Elsevier Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140465/ https://www.ncbi.nlm.nih.gov/pubmed/37120076 http://dx.doi.org/10.1016/j.amjms.2023.04.018 |
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author | Kamata, Kazuhiro Honda, Hitoshi Tokuda, Yasuharu Takamatsu, Akane Taniguchi, Kiyosu Shibuya, Kenji Tabuchi, Takahiro |
author_facet | Kamata, Kazuhiro Honda, Hitoshi Tokuda, Yasuharu Takamatsu, Akane Taniguchi, Kiyosu Shibuya, Kenji Tabuchi, Takahiro |
author_sort | Kamata, Kazuhiro |
collection | PubMed |
description | BACKGROUND: The characteristics and risk factors of post-COVID-19 condition affecting health-related quality of life and the symptom burden are unclear. METHODS: The present, cross-sectional study used the JASTIS (Japan Society and New Tobacco Internet Survey) database. EQ-5D-5L and Somatic Symptom Scale-8 were used to assess health-related quality of life and somatic symptoms, respectively. The participants were classified into a no-COVID-19, COVID-19 not requiring oxygen therapy or COVID-19 requiring oxygen therapy group. First, the entire cohort was analyzed. Then, sensitivity analysis was performed after excluding patients in the no-COVID-19 group with a history of close contact with individuals known to have the disease. FINDINGS: In total, 30130 individuals (mean age: 47.8; females: 51.2%), including 539 and 805 with COVID-19 requiring and not requiring oxygen therapy, respectively, participated. The analysis of the entire cohort as well as the sensitivity analysis demonstrated that individuals with a history of COVID-19 had significantly lower EQ-5D-5L and significantly higher SSS-8 scores than those with no COVID-19 history. The group requiring oxygen therapy was associated with significantly lower EQ-5D-5L and higher SSS-8 scores than the group not requiring oxygen therapy. Propensity-score matching confirmed these results. Furthermore, two or more COVID-19 vaccinations were independently associated with high EQ-5D-5L and low SSS-8 scores (P < 0.001). CONCLUSIONS: The participants with a COVID-19 history, especially those with severe disease, had a significantly higher somatic symptom burden. Analysis after adjusting for potential confounders found that their quality-of-life was also severely affected. Vaccination is crucial to addressing these symptoms, especially in high-risk patients. |
format | Online Article Text |
id | pubmed-10140465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Southern Society for Clinical Investigation. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101404652023-04-28 Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan Kamata, Kazuhiro Honda, Hitoshi Tokuda, Yasuharu Takamatsu, Akane Taniguchi, Kiyosu Shibuya, Kenji Tabuchi, Takahiro Am J Med Sci Clinical Investigation BACKGROUND: The characteristics and risk factors of post-COVID-19 condition affecting health-related quality of life and the symptom burden are unclear. METHODS: The present, cross-sectional study used the JASTIS (Japan Society and New Tobacco Internet Survey) database. EQ-5D-5L and Somatic Symptom Scale-8 were used to assess health-related quality of life and somatic symptoms, respectively. The participants were classified into a no-COVID-19, COVID-19 not requiring oxygen therapy or COVID-19 requiring oxygen therapy group. First, the entire cohort was analyzed. Then, sensitivity analysis was performed after excluding patients in the no-COVID-19 group with a history of close contact with individuals known to have the disease. FINDINGS: In total, 30130 individuals (mean age: 47.8; females: 51.2%), including 539 and 805 with COVID-19 requiring and not requiring oxygen therapy, respectively, participated. The analysis of the entire cohort as well as the sensitivity analysis demonstrated that individuals with a history of COVID-19 had significantly lower EQ-5D-5L and significantly higher SSS-8 scores than those with no COVID-19 history. The group requiring oxygen therapy was associated with significantly lower EQ-5D-5L and higher SSS-8 scores than the group not requiring oxygen therapy. Propensity-score matching confirmed these results. Furthermore, two or more COVID-19 vaccinations were independently associated with high EQ-5D-5L and low SSS-8 scores (P < 0.001). CONCLUSIONS: The participants with a COVID-19 history, especially those with severe disease, had a significantly higher somatic symptom burden. Analysis after adjusting for potential confounders found that their quality-of-life was also severely affected. Vaccination is crucial to addressing these symptoms, especially in high-risk patients. Southern Society for Clinical Investigation. Published by Elsevier Inc. 2023-04-28 /pmc/articles/PMC10140465/ /pubmed/37120076 http://dx.doi.org/10.1016/j.amjms.2023.04.018 Text en © 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Clinical Investigation Kamata, Kazuhiro Honda, Hitoshi Tokuda, Yasuharu Takamatsu, Akane Taniguchi, Kiyosu Shibuya, Kenji Tabuchi, Takahiro Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan |
title | Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan |
title_full | Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan |
title_fullStr | Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan |
title_full_unstemmed | Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan |
title_short | Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan |
title_sort | post-covid health-related quality of life and somatic symptoms: a national survey in japan |
topic | Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140465/ https://www.ncbi.nlm.nih.gov/pubmed/37120076 http://dx.doi.org/10.1016/j.amjms.2023.04.018 |
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