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Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan

BACKGROUND: The characteristics and risk factors of post-COVID-19 condition affecting health-related quality of life and the symptom burden are unclear. METHODS: The present, cross-sectional study used the JASTIS (Japan Society and New Tobacco Internet Survey) database. EQ-5D-5L and Somatic Symptom...

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Autores principales: Kamata, Kazuhiro, Honda, Hitoshi, Tokuda, Yasuharu, Takamatsu, Akane, Taniguchi, Kiyosu, Shibuya, Kenji, Tabuchi, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Southern Society for Clinical Investigation. Published by Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140465/
https://www.ncbi.nlm.nih.gov/pubmed/37120076
http://dx.doi.org/10.1016/j.amjms.2023.04.018
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author Kamata, Kazuhiro
Honda, Hitoshi
Tokuda, Yasuharu
Takamatsu, Akane
Taniguchi, Kiyosu
Shibuya, Kenji
Tabuchi, Takahiro
author_facet Kamata, Kazuhiro
Honda, Hitoshi
Tokuda, Yasuharu
Takamatsu, Akane
Taniguchi, Kiyosu
Shibuya, Kenji
Tabuchi, Takahiro
author_sort Kamata, Kazuhiro
collection PubMed
description BACKGROUND: The characteristics and risk factors of post-COVID-19 condition affecting health-related quality of life and the symptom burden are unclear. METHODS: The present, cross-sectional study used the JASTIS (Japan Society and New Tobacco Internet Survey) database. EQ-5D-5L and Somatic Symptom Scale-8 were used to assess health-related quality of life and somatic symptoms, respectively. The participants were classified into a no-COVID-19, COVID-19 not requiring oxygen therapy or COVID-19 requiring oxygen therapy group. First, the entire cohort was analyzed. Then, sensitivity analysis was performed after excluding patients in the no-COVID-19 group with a history of close contact with individuals known to have the disease. FINDINGS: In total, 30130 individuals (mean age: 47.8; females: 51.2%), including 539 and 805 with COVID-19 requiring and not requiring oxygen therapy, respectively, participated. The analysis of the entire cohort as well as the sensitivity analysis demonstrated that individuals with a history of COVID-19 had significantly lower EQ-5D-5L and significantly higher SSS-8 scores than those with no COVID-19 history. The group requiring oxygen therapy was associated with significantly lower EQ-5D-5L and higher SSS-8 scores than the group not requiring oxygen therapy. Propensity-score matching confirmed these results. Furthermore, two or more COVID-19 vaccinations were independently associated with high EQ-5D-5L and low SSS-8 scores (P < 0.001). CONCLUSIONS: The participants with a COVID-19 history, especially those with severe disease, had a significantly higher somatic symptom burden. Analysis after adjusting for potential confounders found that their quality-of-life was also severely affected. Vaccination is crucial to addressing these symptoms, especially in high-risk patients.
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spelling pubmed-101404652023-04-28 Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan Kamata, Kazuhiro Honda, Hitoshi Tokuda, Yasuharu Takamatsu, Akane Taniguchi, Kiyosu Shibuya, Kenji Tabuchi, Takahiro Am J Med Sci Clinical Investigation BACKGROUND: The characteristics and risk factors of post-COVID-19 condition affecting health-related quality of life and the symptom burden are unclear. METHODS: The present, cross-sectional study used the JASTIS (Japan Society and New Tobacco Internet Survey) database. EQ-5D-5L and Somatic Symptom Scale-8 were used to assess health-related quality of life and somatic symptoms, respectively. The participants were classified into a no-COVID-19, COVID-19 not requiring oxygen therapy or COVID-19 requiring oxygen therapy group. First, the entire cohort was analyzed. Then, sensitivity analysis was performed after excluding patients in the no-COVID-19 group with a history of close contact with individuals known to have the disease. FINDINGS: In total, 30130 individuals (mean age: 47.8; females: 51.2%), including 539 and 805 with COVID-19 requiring and not requiring oxygen therapy, respectively, participated. The analysis of the entire cohort as well as the sensitivity analysis demonstrated that individuals with a history of COVID-19 had significantly lower EQ-5D-5L and significantly higher SSS-8 scores than those with no COVID-19 history. The group requiring oxygen therapy was associated with significantly lower EQ-5D-5L and higher SSS-8 scores than the group not requiring oxygen therapy. Propensity-score matching confirmed these results. Furthermore, two or more COVID-19 vaccinations were independently associated with high EQ-5D-5L and low SSS-8 scores (P < 0.001). CONCLUSIONS: The participants with a COVID-19 history, especially those with severe disease, had a significantly higher somatic symptom burden. Analysis after adjusting for potential confounders found that their quality-of-life was also severely affected. Vaccination is crucial to addressing these symptoms, especially in high-risk patients. Southern Society for Clinical Investigation. Published by Elsevier Inc. 2023-04-28 /pmc/articles/PMC10140465/ /pubmed/37120076 http://dx.doi.org/10.1016/j.amjms.2023.04.018 Text en © 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Clinical Investigation
Kamata, Kazuhiro
Honda, Hitoshi
Tokuda, Yasuharu
Takamatsu, Akane
Taniguchi, Kiyosu
Shibuya, Kenji
Tabuchi, Takahiro
Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan
title Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan
title_full Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan
title_fullStr Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan
title_full_unstemmed Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan
title_short Post-COVID health-related quality of life and somatic symptoms: A national survey in Japan
title_sort post-covid health-related quality of life and somatic symptoms: a national survey in japan
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140465/
https://www.ncbi.nlm.nih.gov/pubmed/37120076
http://dx.doi.org/10.1016/j.amjms.2023.04.018
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