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Meta-analysis of published cerebrospinal fluid proteomics data identifies and validates metabolic enzyme panel as Alzheimer’s disease biomarkers

To develop therapies for Alzheimer’s disease, we need accurate in vivo diagnostics. Multiple proteomic studies mapping biomarker candidates in cerebrospinal fluid (CSF) resulted in little overlap. To overcome this shortcoming, we apply the rarely used concept of proteomics meta-analysis to identify...

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Detalles Bibliográficos
Autores principales: van Zalm, Patrick W., Ahmed, Saima, Fatou, Benoit, Schreiber, Rudy, Barnaby, Omar, Boxer, Adam, Zetterberg, Henrik, Steen, Judith A., Steen, Hanno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140596/
https://www.ncbi.nlm.nih.gov/pubmed/37075703
http://dx.doi.org/10.1016/j.xcrm.2023.101005