Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH

Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease globally and a leading cause for liver transplantation in the US. Its pathogenesis remains imprecisely defined. We combined two high-resolution modalities to tissue samples from NASH clinical trials, machine learning (ML)-b...

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Detalles Bibliográficos
Autores principales: Conway, Jake, Pouryahya, Maryam, Gindin, Yevgeniy, Pan, David Z., Carrasco-Zevallos, Oscar M., Mountain, Victoria, Subramanian, G. Mani, Montalto, Michael C., Resnick, Murray, Beck, Andrew H., Huss, Ryan S., Myers, Robert P., Taylor-Weiner, Amaro, Wapinski, Ilan, Chung, Chuhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140650/
https://www.ncbi.nlm.nih.gov/pubmed/37075704
http://dx.doi.org/10.1016/j.xcrm.2023.101016

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