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Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications

Wounds produced by trauma, burns, and chronic diseases cause millions of patients to suffer discomfort, pain, and, in many cases, disability and death, leading to enormous health, social and financial impacts globally. Regrettably, current clinical treatments for chronic wounds remain unsatisfactory...

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Detalles Bibliográficos
Autores principales: Mansur, A. A. P., Rodrigues, M. A., Capanema, N. S. V., Carvalho, S. M., Gomes, D. A., Mansur, H. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140670/
https://www.ncbi.nlm.nih.gov/pubmed/37124005
http://dx.doi.org/10.1039/d3ra01519j
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author Mansur, A. A. P.
Rodrigues, M. A.
Capanema, N. S. V.
Carvalho, S. M.
Gomes, D. A.
Mansur, H. S.
author_facet Mansur, A. A. P.
Rodrigues, M. A.
Capanema, N. S. V.
Carvalho, S. M.
Gomes, D. A.
Mansur, H. S.
author_sort Mansur, A. A. P.
collection PubMed
description Wounds produced by trauma, burns, and chronic diseases cause millions of patients to suffer discomfort, pain, and, in many cases, disability and death, leading to enormous health, social and financial impacts globally. Regrettably, current clinical treatments for chronic wounds remain unsatisfactory. Thus, this study reports for the first time the design, development, and synthesis of chemically biofunctionalized hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked by citric acid using an entirely biocompatible and green process. They demonstrated suitable physicochemical properties, cytocompatibility, and hemocompatibility to be applied as a smart wound dressing for skin tissue engineering. These novel hybrids were biofunctionalized with l-arginine and RGD peptide through carbodiimide mediated-amide formation to promote bioadhesion of fibroblast and keratinocyte cells as a potential enhancement for wound healing and skin tissue engineering applications.
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spelling pubmed-101406702023-04-29 Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications Mansur, A. A. P. Rodrigues, M. A. Capanema, N. S. V. Carvalho, S. M. Gomes, D. A. Mansur, H. S. RSC Adv Chemistry Wounds produced by trauma, burns, and chronic diseases cause millions of patients to suffer discomfort, pain, and, in many cases, disability and death, leading to enormous health, social and financial impacts globally. Regrettably, current clinical treatments for chronic wounds remain unsatisfactory. Thus, this study reports for the first time the design, development, and synthesis of chemically biofunctionalized hybrid hydrogels made of carboxymethyl cellulose (CMC) and poly(vinyl alcohol) (PVA) crosslinked by citric acid using an entirely biocompatible and green process. They demonstrated suitable physicochemical properties, cytocompatibility, and hemocompatibility to be applied as a smart wound dressing for skin tissue engineering. These novel hybrids were biofunctionalized with l-arginine and RGD peptide through carbodiimide mediated-amide formation to promote bioadhesion of fibroblast and keratinocyte cells as a potential enhancement for wound healing and skin tissue engineering applications. The Royal Society of Chemistry 2023-04-28 /pmc/articles/PMC10140670/ /pubmed/37124005 http://dx.doi.org/10.1039/d3ra01519j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Mansur, A. A. P.
Rodrigues, M. A.
Capanema, N. S. V.
Carvalho, S. M.
Gomes, D. A.
Mansur, H. S.
Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications
title Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications
title_full Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications
title_fullStr Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications
title_full_unstemmed Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications
title_short Functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications
title_sort functionalized bioadhesion-enhanced carboxymethyl cellulose/polyvinyl alcohol hybrid hydrogels for chronic wound dressing applications
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140670/
https://www.ncbi.nlm.nih.gov/pubmed/37124005
http://dx.doi.org/10.1039/d3ra01519j
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