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Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study

BACKGROUND: Acute psychological stress can provoke mental stress-induced myocardial ischemia (MSIMI) in coronary artery disease (CAD). Stromal cell-derived factor 1 (SDF1) is released in response to hypoxia, and higher levels of SDF1 are associated with adverse outcomes. We examined whether an incre...

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Autores principales: Kim, Jeong Hwan, Almuwaqqat, Zakaria, Martini, Afif, Liu, Chang, Ko, Yi-An, Sullivan, Samaah, Dong, Tiffany, Shah, Amit J., Bremner, J. Douglas, Pearce, Brad D., Nye, Jonathan A., Vaccarino, Viola, Quyyumi, Arshed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140748/
https://www.ncbi.nlm.nih.gov/pubmed/37124969
http://dx.doi.org/10.1016/j.cjco.2023.01.006
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author Kim, Jeong Hwan
Almuwaqqat, Zakaria
Martini, Afif
Liu, Chang
Ko, Yi-An
Sullivan, Samaah
Dong, Tiffany
Shah, Amit J.
Bremner, J. Douglas
Pearce, Brad D.
Nye, Jonathan A.
Vaccarino, Viola
Quyyumi, Arshed A.
author_facet Kim, Jeong Hwan
Almuwaqqat, Zakaria
Martini, Afif
Liu, Chang
Ko, Yi-An
Sullivan, Samaah
Dong, Tiffany
Shah, Amit J.
Bremner, J. Douglas
Pearce, Brad D.
Nye, Jonathan A.
Vaccarino, Viola
Quyyumi, Arshed A.
author_sort Kim, Jeong Hwan
collection PubMed
description BACKGROUND: Acute psychological stress can provoke mental stress-induced myocardial ischemia (MSIMI) in coronary artery disease (CAD). Stromal cell-derived factor 1 (SDF1) is released in response to hypoxia, and higher levels of SDF1 are associated with adverse outcomes. We examined whether an increase in SDF1 level in response to mental stress predicts adverse outcomes in CAD patients. METHODS: A total of 554 patients with stable CAD (mean age 63 years; 76% male; 26% Black) underwent standardized mental stress testing. Plasma SDF1 levels were measured at rest and 90 minutes after mental stress, and MSIMI was evaluated by 99mTc-sestamibi perfusion imaging. Participants were followed for 5 years for the primary endpoint of composite of death and myocardial infarction (MI) and the secondary endpoint of composite of death, MI, and heart failure hospitalization. Cox hazard models were used to assess the association between SDF1 change and incident adverse events. RESULTS: Mean (standard deviation) SDF1 change with mental stress was +56.0 (230) pg/mL. During follow-up, a rise of 1 standard deviation in SDF1 with mental stress was associated with a 32% higher risk for the primary endpoint of death and MI (95% confidence interval, 6%-64%), independent of the resting SDF1 level, demographic and clinical risk factors, and presence of ischemia. A rise of 1 standard deviation in SDF1 was associated with a 33% (95% confidence interval, 11%-59%) increase in the risk for the secondary endpoint, independent of the resting SDF1 level, demographic, and clinical risk factors and presence of ischemia. CONCLUSIONS: An increase in SDF1 level in response to mental stress is associated with a higher risk of adverse events in stable CAD, independent of MSIMI.
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spelling pubmed-101407482023-04-29 Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study Kim, Jeong Hwan Almuwaqqat, Zakaria Martini, Afif Liu, Chang Ko, Yi-An Sullivan, Samaah Dong, Tiffany Shah, Amit J. Bremner, J. Douglas Pearce, Brad D. Nye, Jonathan A. Vaccarino, Viola Quyyumi, Arshed A. CJC Open Original Article BACKGROUND: Acute psychological stress can provoke mental stress-induced myocardial ischemia (MSIMI) in coronary artery disease (CAD). Stromal cell-derived factor 1 (SDF1) is released in response to hypoxia, and higher levels of SDF1 are associated with adverse outcomes. We examined whether an increase in SDF1 level in response to mental stress predicts adverse outcomes in CAD patients. METHODS: A total of 554 patients with stable CAD (mean age 63 years; 76% male; 26% Black) underwent standardized mental stress testing. Plasma SDF1 levels were measured at rest and 90 minutes after mental stress, and MSIMI was evaluated by 99mTc-sestamibi perfusion imaging. Participants were followed for 5 years for the primary endpoint of composite of death and myocardial infarction (MI) and the secondary endpoint of composite of death, MI, and heart failure hospitalization. Cox hazard models were used to assess the association between SDF1 change and incident adverse events. RESULTS: Mean (standard deviation) SDF1 change with mental stress was +56.0 (230) pg/mL. During follow-up, a rise of 1 standard deviation in SDF1 with mental stress was associated with a 32% higher risk for the primary endpoint of death and MI (95% confidence interval, 6%-64%), independent of the resting SDF1 level, demographic and clinical risk factors, and presence of ischemia. A rise of 1 standard deviation in SDF1 was associated with a 33% (95% confidence interval, 11%-59%) increase in the risk for the secondary endpoint, independent of the resting SDF1 level, demographic, and clinical risk factors and presence of ischemia. CONCLUSIONS: An increase in SDF1 level in response to mental stress is associated with a higher risk of adverse events in stable CAD, independent of MSIMI. Elsevier 2023-01-28 /pmc/articles/PMC10140748/ /pubmed/37124969 http://dx.doi.org/10.1016/j.cjco.2023.01.006 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Kim, Jeong Hwan
Almuwaqqat, Zakaria
Martini, Afif
Liu, Chang
Ko, Yi-An
Sullivan, Samaah
Dong, Tiffany
Shah, Amit J.
Bremner, J. Douglas
Pearce, Brad D.
Nye, Jonathan A.
Vaccarino, Viola
Quyyumi, Arshed A.
Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study
title Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study
title_full Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study
title_fullStr Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study
title_full_unstemmed Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study
title_short Mental Stress-Induced Change in Plasma Stromal Cell-Derived Factor-1 and Adverse Cardiovascular Outcomes: A Cohort Study
title_sort mental stress-induced change in plasma stromal cell-derived factor-1 and adverse cardiovascular outcomes: a cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140748/
https://www.ncbi.nlm.nih.gov/pubmed/37124969
http://dx.doi.org/10.1016/j.cjco.2023.01.006
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