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Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals
Different nutritional regimens have been reported to exert beneficial effects on obesity through the regulation of the composition and function of gut microbiota. In this context, we conducted in obese subjects two dietary interventions consisting of a low-calorie and two-phase (ketogenic plus low-c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140827/ https://www.ncbi.nlm.nih.gov/pubmed/37111060 http://dx.doi.org/10.3390/nu15081841 |
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author | Carelli, Laurie Lynn D’Aquila, Patrizia Rango, Francesco De Incorvaia, Armida Sena, Giada Passarino, Giuseppe Bellizzi, Dina |
author_facet | Carelli, Laurie Lynn D’Aquila, Patrizia Rango, Francesco De Incorvaia, Armida Sena, Giada Passarino, Giuseppe Bellizzi, Dina |
author_sort | Carelli, Laurie Lynn |
collection | PubMed |
description | Different nutritional regimens have been reported to exert beneficial effects on obesity through the regulation of the composition and function of gut microbiota. In this context, we conducted in obese subjects two dietary interventions consisting of a low-calorie and two-phase (ketogenic plus low-calorie) diet for 8 weeks. Anthropometric and clinical parameters were evaluated at baseline and following the two diets, and gut microbiota composition was assessed by 16S rRNA gene sequencing. A significant reduction was observed for abdominal circumference and insulin levels in the subjects following the two-phase diet. Significant differences in gut microbial composition were observed after treatment compared to the baseline. Both diets induced taxonomic shifts including a decrease in Proteobacteria, which are recognized as dysbiosis markers and enrichment of Verrucomicrobiaceae, which has recently emerged as an effective probiotic. An increase in Bacteroidetes, constituting the so-called good bacteria, was observable only in the two-phase diet. These findings provide evidence that a targeted nutritional regimen and an appropriate use of probiotics can modulate gut microbiota to reach a favorable composition and achieve the balance often compromised by different pathologies and conditions, such as obesity. |
format | Online Article Text |
id | pubmed-10140827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101408272023-04-29 Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals Carelli, Laurie Lynn D’Aquila, Patrizia Rango, Francesco De Incorvaia, Armida Sena, Giada Passarino, Giuseppe Bellizzi, Dina Nutrients Article Different nutritional regimens have been reported to exert beneficial effects on obesity through the regulation of the composition and function of gut microbiota. In this context, we conducted in obese subjects two dietary interventions consisting of a low-calorie and two-phase (ketogenic plus low-calorie) diet for 8 weeks. Anthropometric and clinical parameters were evaluated at baseline and following the two diets, and gut microbiota composition was assessed by 16S rRNA gene sequencing. A significant reduction was observed for abdominal circumference and insulin levels in the subjects following the two-phase diet. Significant differences in gut microbial composition were observed after treatment compared to the baseline. Both diets induced taxonomic shifts including a decrease in Proteobacteria, which are recognized as dysbiosis markers and enrichment of Verrucomicrobiaceae, which has recently emerged as an effective probiotic. An increase in Bacteroidetes, constituting the so-called good bacteria, was observable only in the two-phase diet. These findings provide evidence that a targeted nutritional regimen and an appropriate use of probiotics can modulate gut microbiota to reach a favorable composition and achieve the balance often compromised by different pathologies and conditions, such as obesity. MDPI 2023-04-11 /pmc/articles/PMC10140827/ /pubmed/37111060 http://dx.doi.org/10.3390/nu15081841 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carelli, Laurie Lynn D’Aquila, Patrizia Rango, Francesco De Incorvaia, Armida Sena, Giada Passarino, Giuseppe Bellizzi, Dina Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals |
title | Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals |
title_full | Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals |
title_fullStr | Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals |
title_full_unstemmed | Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals |
title_short | Modulation of Gut Microbiota through Low-Calorie and Two-Phase Diets in Obese Individuals |
title_sort | modulation of gut microbiota through low-calorie and two-phase diets in obese individuals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140827/ https://www.ncbi.nlm.nih.gov/pubmed/37111060 http://dx.doi.org/10.3390/nu15081841 |
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