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The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration
Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous system and in sensory structures including olfactory and auditory systems. Many studies have highlighted the protective effects of BDNF in the brain, showing how it can promote neuronal growth and survival and mod...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140880/ https://www.ncbi.nlm.nih.gov/pubmed/37109038 http://dx.doi.org/10.3390/jpm13040652 |
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author | Pisani, Anna Paciello, Fabiola Del Vecchio, Valeria Malesci, Rita De Corso, Eugenio Cantone, Elena Fetoni, Anna Rita |
author_facet | Pisani, Anna Paciello, Fabiola Del Vecchio, Valeria Malesci, Rita De Corso, Eugenio Cantone, Elena Fetoni, Anna Rita |
author_sort | Pisani, Anna |
collection | PubMed |
description | Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous system and in sensory structures including olfactory and auditory systems. Many studies have highlighted the protective effects of BDNF in the brain, showing how it can promote neuronal growth and survival and modulate synaptic plasticity. On the other hand, conflicting data about BDNF expression and functions in the cochlear and in olfactory structures have been reported. Several clinical and experimental research studies showed alterations in BDNF levels in neurodegenerative diseases affecting the central and peripheral nervous system, suggesting that BDNF can be a promising biomarker in most neurodegenerative conditions, including Alzheimer’s disease, shearing loss, or olfactory impairment. Here, we summarize current research concerning BDNF functions in brain and in sensory domains (olfaction and hearing), focusing on the effects of the BDNF/TrkB signalling pathway activation in both physiological and pathological conditions. Finally, we review significant studies highlighting the possibility to target BDNF as a biomarker in early diagnosis of sensory and cognitive neurodegeneration, opening new opportunities to develop effective therapeutic strategies aimed to counteract neurodegeneration. |
format | Online Article Text |
id | pubmed-10140880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101408802023-04-29 The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration Pisani, Anna Paciello, Fabiola Del Vecchio, Valeria Malesci, Rita De Corso, Eugenio Cantone, Elena Fetoni, Anna Rita J Pers Med Review Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous system and in sensory structures including olfactory and auditory systems. Many studies have highlighted the protective effects of BDNF in the brain, showing how it can promote neuronal growth and survival and modulate synaptic plasticity. On the other hand, conflicting data about BDNF expression and functions in the cochlear and in olfactory structures have been reported. Several clinical and experimental research studies showed alterations in BDNF levels in neurodegenerative diseases affecting the central and peripheral nervous system, suggesting that BDNF can be a promising biomarker in most neurodegenerative conditions, including Alzheimer’s disease, shearing loss, or olfactory impairment. Here, we summarize current research concerning BDNF functions in brain and in sensory domains (olfaction and hearing), focusing on the effects of the BDNF/TrkB signalling pathway activation in both physiological and pathological conditions. Finally, we review significant studies highlighting the possibility to target BDNF as a biomarker in early diagnosis of sensory and cognitive neurodegeneration, opening new opportunities to develop effective therapeutic strategies aimed to counteract neurodegeneration. MDPI 2023-04-10 /pmc/articles/PMC10140880/ /pubmed/37109038 http://dx.doi.org/10.3390/jpm13040652 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pisani, Anna Paciello, Fabiola Del Vecchio, Valeria Malesci, Rita De Corso, Eugenio Cantone, Elena Fetoni, Anna Rita The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration |
title | The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration |
title_full | The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration |
title_fullStr | The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration |
title_full_unstemmed | The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration |
title_short | The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration |
title_sort | role of bdnf as a biomarker in cognitive and sensory neurodegeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140880/ https://www.ncbi.nlm.nih.gov/pubmed/37109038 http://dx.doi.org/10.3390/jpm13040652 |
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