Regioselective Reaction of 2-Indolylmethanols with Enamides

A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl(3) as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the eff...

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Detalles Bibliográficos
Autores principales: Tian, Yuting, He, Dongqing, Gao, Limei, Zou, Yu, Liu, Xiaoshuang, Wang, Qiang, Liang, Enxiang, Zheng, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140953/
https://www.ncbi.nlm.nih.gov/pubmed/37110576
http://dx.doi.org/10.3390/molecules28083341
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author Tian, Yuting
He, Dongqing
Gao, Limei
Zou, Yu
Liu, Xiaoshuang
Wang, Qiang
Liang, Enxiang
Zheng, Yongsheng
author_facet Tian, Yuting
He, Dongqing
Gao, Limei
Zou, Yu
Liu, Xiaoshuang
Wang, Qiang
Liang, Enxiang
Zheng, Yongsheng
author_sort Tian, Yuting
collection PubMed
description A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl(3) as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids.
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spelling pubmed-101409532023-04-29 Regioselective Reaction of 2-Indolylmethanols with Enamides Tian, Yuting He, Dongqing Gao, Limei Zou, Yu Liu, Xiaoshuang Wang, Qiang Liang, Enxiang Zheng, Yongsheng Molecules Communication A highly regioselective reaction of 2-indolylmethanols with enamides has been developed at room temperature by using AlCl(3) as a catalyst. A wide range of hybrids (40 examples) of indoles and enamides were obtained in moderate to good yields (up to 98% yield). This transformation represents the efficient way to introduce biologically important indoles and enamides skeleton into structurally complex hybrids. MDPI 2023-04-10 /pmc/articles/PMC10140953/ /pubmed/37110576 http://dx.doi.org/10.3390/molecules28083341 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Tian, Yuting
He, Dongqing
Gao, Limei
Zou, Yu
Liu, Xiaoshuang
Wang, Qiang
Liang, Enxiang
Zheng, Yongsheng
Regioselective Reaction of 2-Indolylmethanols with Enamides
title Regioselective Reaction of 2-Indolylmethanols with Enamides
title_full Regioselective Reaction of 2-Indolylmethanols with Enamides
title_fullStr Regioselective Reaction of 2-Indolylmethanols with Enamides
title_full_unstemmed Regioselective Reaction of 2-Indolylmethanols with Enamides
title_short Regioselective Reaction of 2-Indolylmethanols with Enamides
title_sort regioselective reaction of 2-indolylmethanols with enamides
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140953/
https://www.ncbi.nlm.nih.gov/pubmed/37110576
http://dx.doi.org/10.3390/molecules28083341
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