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Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation

Background: Frequent premature ventricular complexes (PVCs) can cause PVC-induced cardiomyopathy. The value of PVC ablation in patients with preserved left ventricular function in the low–normal range (ejection fraction: 50–55%) is not established. Strain analysis has been used to estimate changes i...

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Autores principales: Jamé, Sina, Liu, Zhigang, Kolias, Theodore, Liang, Jackson, Labounty, Troy, Ghannam, Michael, Latchamsetty, Rakesh, Jongnarangsin, Krit, Morady, Fred, Bogun, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140973/
https://www.ncbi.nlm.nih.gov/pubmed/37109352
http://dx.doi.org/10.3390/jcm12083017
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author Jamé, Sina
Liu, Zhigang
Kolias, Theodore
Liang, Jackson
Labounty, Troy
Ghannam, Michael
Latchamsetty, Rakesh
Jongnarangsin, Krit
Morady, Fred
Bogun, Frank
author_facet Jamé, Sina
Liu, Zhigang
Kolias, Theodore
Liang, Jackson
Labounty, Troy
Ghannam, Michael
Latchamsetty, Rakesh
Jongnarangsin, Krit
Morady, Fred
Bogun, Frank
author_sort Jamé, Sina
collection PubMed
description Background: Frequent premature ventricular complexes (PVCs) can cause PVC-induced cardiomyopathy. The value of PVC ablation in patients with preserved left ventricular function in the low–normal range (ejection fraction: 50–55%) is not established. Strain analysis has been used to estimate changes in left ventricular function beyond assessment of the ejection fraction (EF). Longitudinal strain has been proposed as a method to detect changes over time in the setting of frequent asymptomatic premature ventricular complexes and preserved left ventricular (LV) function. A decrease in strain may be evidence of PVC-induced cardiomyopathy. Objective: In this study, we assessed the role of PVC ablation in patients with low–normal EF and the effect on EF and myocardial strain before and after PVC ablation. Methods: A total of 70 consecutive patients with either low–normal EF (0.5–<0.55, n = 35) or high–normal EF (≥0.55; n = 35), using available imaging and Holter data, were referred for ablation due to frequent PVCs. EF and longitudinal strain were assessed pre- and post-ablation. Results: There was a significant increase in EF (53.2 ± 0.4% to 58.3 ± 0.5%, p < 0.001) and improvement in longitudinal strain (−15.2 ± 3.3 to −16.6 ± 3, p = 0.007) post-ablation in patients with low–normal EF and successful ablation. There was no change in EF or longitudinal strain in patients with high–normal EF and a successful ablation pre- vs. post-ablation. Conclusions: Patients with frequent PVCs and low–normal LV EF compared to patients with frequent PVCs and high–normal LV EF have evidence of PVC-induced cardiomyopathy and may benefit from ablation despite a preserved left ventricular EF.
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spelling pubmed-101409732023-04-29 Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation Jamé, Sina Liu, Zhigang Kolias, Theodore Liang, Jackson Labounty, Troy Ghannam, Michael Latchamsetty, Rakesh Jongnarangsin, Krit Morady, Fred Bogun, Frank J Clin Med Brief Report Background: Frequent premature ventricular complexes (PVCs) can cause PVC-induced cardiomyopathy. The value of PVC ablation in patients with preserved left ventricular function in the low–normal range (ejection fraction: 50–55%) is not established. Strain analysis has been used to estimate changes in left ventricular function beyond assessment of the ejection fraction (EF). Longitudinal strain has been proposed as a method to detect changes over time in the setting of frequent asymptomatic premature ventricular complexes and preserved left ventricular (LV) function. A decrease in strain may be evidence of PVC-induced cardiomyopathy. Objective: In this study, we assessed the role of PVC ablation in patients with low–normal EF and the effect on EF and myocardial strain before and after PVC ablation. Methods: A total of 70 consecutive patients with either low–normal EF (0.5–<0.55, n = 35) or high–normal EF (≥0.55; n = 35), using available imaging and Holter data, were referred for ablation due to frequent PVCs. EF and longitudinal strain were assessed pre- and post-ablation. Results: There was a significant increase in EF (53.2 ± 0.4% to 58.3 ± 0.5%, p < 0.001) and improvement in longitudinal strain (−15.2 ± 3.3 to −16.6 ± 3, p = 0.007) post-ablation in patients with low–normal EF and successful ablation. There was no change in EF or longitudinal strain in patients with high–normal EF and a successful ablation pre- vs. post-ablation. Conclusions: Patients with frequent PVCs and low–normal LV EF compared to patients with frequent PVCs and high–normal LV EF have evidence of PVC-induced cardiomyopathy and may benefit from ablation despite a preserved left ventricular EF. MDPI 2023-04-21 /pmc/articles/PMC10140973/ /pubmed/37109352 http://dx.doi.org/10.3390/jcm12083017 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Jamé, Sina
Liu, Zhigang
Kolias, Theodore
Liang, Jackson
Labounty, Troy
Ghannam, Michael
Latchamsetty, Rakesh
Jongnarangsin, Krit
Morady, Fred
Bogun, Frank
Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation
title Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation
title_full Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation
title_fullStr Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation
title_full_unstemmed Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation
title_short Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation
title_sort strain analysis in patients with frequent premature ventricular complexes and preserved left ventricular function undergoing ablation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140973/
https://www.ncbi.nlm.nih.gov/pubmed/37109352
http://dx.doi.org/10.3390/jcm12083017
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