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Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation
Background: Frequent premature ventricular complexes (PVCs) can cause PVC-induced cardiomyopathy. The value of PVC ablation in patients with preserved left ventricular function in the low–normal range (ejection fraction: 50–55%) is not established. Strain analysis has been used to estimate changes i...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140973/ https://www.ncbi.nlm.nih.gov/pubmed/37109352 http://dx.doi.org/10.3390/jcm12083017 |
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author | Jamé, Sina Liu, Zhigang Kolias, Theodore Liang, Jackson Labounty, Troy Ghannam, Michael Latchamsetty, Rakesh Jongnarangsin, Krit Morady, Fred Bogun, Frank |
author_facet | Jamé, Sina Liu, Zhigang Kolias, Theodore Liang, Jackson Labounty, Troy Ghannam, Michael Latchamsetty, Rakesh Jongnarangsin, Krit Morady, Fred Bogun, Frank |
author_sort | Jamé, Sina |
collection | PubMed |
description | Background: Frequent premature ventricular complexes (PVCs) can cause PVC-induced cardiomyopathy. The value of PVC ablation in patients with preserved left ventricular function in the low–normal range (ejection fraction: 50–55%) is not established. Strain analysis has been used to estimate changes in left ventricular function beyond assessment of the ejection fraction (EF). Longitudinal strain has been proposed as a method to detect changes over time in the setting of frequent asymptomatic premature ventricular complexes and preserved left ventricular (LV) function. A decrease in strain may be evidence of PVC-induced cardiomyopathy. Objective: In this study, we assessed the role of PVC ablation in patients with low–normal EF and the effect on EF and myocardial strain before and after PVC ablation. Methods: A total of 70 consecutive patients with either low–normal EF (0.5–<0.55, n = 35) or high–normal EF (≥0.55; n = 35), using available imaging and Holter data, were referred for ablation due to frequent PVCs. EF and longitudinal strain were assessed pre- and post-ablation. Results: There was a significant increase in EF (53.2 ± 0.4% to 58.3 ± 0.5%, p < 0.001) and improvement in longitudinal strain (−15.2 ± 3.3 to −16.6 ± 3, p = 0.007) post-ablation in patients with low–normal EF and successful ablation. There was no change in EF or longitudinal strain in patients with high–normal EF and a successful ablation pre- vs. post-ablation. Conclusions: Patients with frequent PVCs and low–normal LV EF compared to patients with frequent PVCs and high–normal LV EF have evidence of PVC-induced cardiomyopathy and may benefit from ablation despite a preserved left ventricular EF. |
format | Online Article Text |
id | pubmed-10140973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101409732023-04-29 Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation Jamé, Sina Liu, Zhigang Kolias, Theodore Liang, Jackson Labounty, Troy Ghannam, Michael Latchamsetty, Rakesh Jongnarangsin, Krit Morady, Fred Bogun, Frank J Clin Med Brief Report Background: Frequent premature ventricular complexes (PVCs) can cause PVC-induced cardiomyopathy. The value of PVC ablation in patients with preserved left ventricular function in the low–normal range (ejection fraction: 50–55%) is not established. Strain analysis has been used to estimate changes in left ventricular function beyond assessment of the ejection fraction (EF). Longitudinal strain has been proposed as a method to detect changes over time in the setting of frequent asymptomatic premature ventricular complexes and preserved left ventricular (LV) function. A decrease in strain may be evidence of PVC-induced cardiomyopathy. Objective: In this study, we assessed the role of PVC ablation in patients with low–normal EF and the effect on EF and myocardial strain before and after PVC ablation. Methods: A total of 70 consecutive patients with either low–normal EF (0.5–<0.55, n = 35) or high–normal EF (≥0.55; n = 35), using available imaging and Holter data, were referred for ablation due to frequent PVCs. EF and longitudinal strain were assessed pre- and post-ablation. Results: There was a significant increase in EF (53.2 ± 0.4% to 58.3 ± 0.5%, p < 0.001) and improvement in longitudinal strain (−15.2 ± 3.3 to −16.6 ± 3, p = 0.007) post-ablation in patients with low–normal EF and successful ablation. There was no change in EF or longitudinal strain in patients with high–normal EF and a successful ablation pre- vs. post-ablation. Conclusions: Patients with frequent PVCs and low–normal LV EF compared to patients with frequent PVCs and high–normal LV EF have evidence of PVC-induced cardiomyopathy and may benefit from ablation despite a preserved left ventricular EF. MDPI 2023-04-21 /pmc/articles/PMC10140973/ /pubmed/37109352 http://dx.doi.org/10.3390/jcm12083017 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Jamé, Sina Liu, Zhigang Kolias, Theodore Liang, Jackson Labounty, Troy Ghannam, Michael Latchamsetty, Rakesh Jongnarangsin, Krit Morady, Fred Bogun, Frank Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation |
title | Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation |
title_full | Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation |
title_fullStr | Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation |
title_full_unstemmed | Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation |
title_short | Strain Analysis in Patients with Frequent Premature Ventricular Complexes and Preserved Left Ventricular Function Undergoing Ablation |
title_sort | strain analysis in patients with frequent premature ventricular complexes and preserved left ventricular function undergoing ablation |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140973/ https://www.ncbi.nlm.nih.gov/pubmed/37109352 http://dx.doi.org/10.3390/jcm12083017 |
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