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Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis

Over the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detectio...

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Autores principales: Zaid, Atiqah, Hassan, Norfarizah Hanim, Marriott, Philip J., Wong, Yong Foo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140985/
https://www.ncbi.nlm.nih.gov/pubmed/37111606
http://dx.doi.org/10.3390/pharmaceutics15041121
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author Zaid, Atiqah
Hassan, Norfarizah Hanim
Marriott, Philip J.
Wong, Yong Foo
author_facet Zaid, Atiqah
Hassan, Norfarizah Hanim
Marriott, Philip J.
Wong, Yong Foo
author_sort Zaid, Atiqah
collection PubMed
description Over the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detection modalities for drug discovery and analysis, which ideally improve the screening and identification of disease biomarkers, as well as monitoring of therapeutic responses to treatment in complex biological matrixes. Selected recent GC×GC applications that focus on such biomarkers and metabolite profiling of the effects of drug administration are covered. In particular, the technical overview of recent GC×GC implementation with hyphenation to the key mass spectrometry (MS) technologies that provide the benefit of enhanced separation dimension analysis with MS domain differentiation is discussed. We conclude by highlighting the challenges in GC×GC for drug discovery and development with perspectives on future trends.
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spelling pubmed-101409852023-04-29 Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis Zaid, Atiqah Hassan, Norfarizah Hanim Marriott, Philip J. Wong, Yong Foo Pharmaceutics Review Over the last decades, comprehensive two-dimensional gas chromatography (GC×GC) has emerged as a significant separation tool for high-resolution analysis of disease-associated metabolites and pharmaceutically relevant molecules. This review highlights recent advances of GC×GC with different detection modalities for drug discovery and analysis, which ideally improve the screening and identification of disease biomarkers, as well as monitoring of therapeutic responses to treatment in complex biological matrixes. Selected recent GC×GC applications that focus on such biomarkers and metabolite profiling of the effects of drug administration are covered. In particular, the technical overview of recent GC×GC implementation with hyphenation to the key mass spectrometry (MS) technologies that provide the benefit of enhanced separation dimension analysis with MS domain differentiation is discussed. We conclude by highlighting the challenges in GC×GC for drug discovery and development with perspectives on future trends. MDPI 2023-03-31 /pmc/articles/PMC10140985/ /pubmed/37111606 http://dx.doi.org/10.3390/pharmaceutics15041121 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zaid, Atiqah
Hassan, Norfarizah Hanim
Marriott, Philip J.
Wong, Yong Foo
Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
title Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
title_full Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
title_fullStr Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
title_full_unstemmed Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
title_short Comprehensive Two-Dimensional Gas Chromatography as a Bioanalytical Platform for Drug Discovery and Analysis
title_sort comprehensive two-dimensional gas chromatography as a bioanalytical platform for drug discovery and analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140985/
https://www.ncbi.nlm.nih.gov/pubmed/37111606
http://dx.doi.org/10.3390/pharmaceutics15041121
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