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Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses

The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses. One of the host antiviral defenses is the nonsense-mediated mRNA decay (NMD), an evolutionarily c...

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Detalles Bibliográficos
Autores principales: Ahmed, Md Robel, Du, Zhiyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141005/
https://www.ncbi.nlm.nih.gov/pubmed/37112798
http://dx.doi.org/10.3390/v15040816
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author Ahmed, Md Robel
Du, Zhiyou
author_facet Ahmed, Md Robel
Du, Zhiyou
author_sort Ahmed, Md Robel
collection PubMed
description The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses. One of the host antiviral defenses is the nonsense-mediated mRNA decay (NMD), an evolutionarily conserved mechanism for RNA quality control in eukaryotic cells. NMD ensures the accuracy of mRNA translation by removing the abnormal mRNAs harboring pre-matured stop codons. Many RNA viruses have a genome that contains internal stop codon(s) (iTC). Akin to the premature termination codon in aberrant RNA transcripts, the presence of iTC would activate NMD to degrade iTC-containing viral genomes. A couple of viruses have been reported to be sensitive to the NMD-mediated antiviral defense, while some viruses have evolved with specific cis-acting RNA features or trans-acting viral proteins to overcome or escape from NMD. Recently, increasing light has been shed on the NMD–virus interaction. This review summarizes the current scenario of NMD-mediated viral RNA degradation and classifies various molecular means by which viruses compromise the NMD-mediated antiviral defense for better infection in their hosts.
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spelling pubmed-101410052023-04-29 Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses Ahmed, Md Robel Du, Zhiyou Viruses Review The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses. One of the host antiviral defenses is the nonsense-mediated mRNA decay (NMD), an evolutionarily conserved mechanism for RNA quality control in eukaryotic cells. NMD ensures the accuracy of mRNA translation by removing the abnormal mRNAs harboring pre-matured stop codons. Many RNA viruses have a genome that contains internal stop codon(s) (iTC). Akin to the premature termination codon in aberrant RNA transcripts, the presence of iTC would activate NMD to degrade iTC-containing viral genomes. A couple of viruses have been reported to be sensitive to the NMD-mediated antiviral defense, while some viruses have evolved with specific cis-acting RNA features or trans-acting viral proteins to overcome or escape from NMD. Recently, increasing light has been shed on the NMD–virus interaction. This review summarizes the current scenario of NMD-mediated viral RNA degradation and classifies various molecular means by which viruses compromise the NMD-mediated antiviral defense for better infection in their hosts. MDPI 2023-03-23 /pmc/articles/PMC10141005/ /pubmed/37112798 http://dx.doi.org/10.3390/v15040816 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ahmed, Md Robel
Du, Zhiyou
Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
title Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
title_full Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
title_fullStr Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
title_full_unstemmed Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
title_short Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
title_sort molecular interaction of nonsense-mediated mrna decay with viruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141005/
https://www.ncbi.nlm.nih.gov/pubmed/37112798
http://dx.doi.org/10.3390/v15040816
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