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Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination

Continuous evaluation of the coronavirus disease 2019 (COVID-19) vaccine effectiveness in hemodialysis (HD) patients is critical in this immunocompromised patient group with higher mortality rates due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The response towards vac...

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Autores principales: Gonzalez-Perez, Maria, Baranda, Jana, Berges-Buxeda, Marcos J., Conde, Patricia, Pérez-Olmeda, Mayte, Lozano-Ojalvo, Daniel, Cámara, Carmen, del Rosario Llópez-Carratalá, Maria, Gonzalez-Parra, Emilio, Portolés, Pilar, Ortiz, Alberto, Portoles, Jose, Ochando, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141011/
https://www.ncbi.nlm.nih.gov/pubmed/37111331
http://dx.doi.org/10.3390/ph16040574
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author Gonzalez-Perez, Maria
Baranda, Jana
Berges-Buxeda, Marcos J.
Conde, Patricia
Pérez-Olmeda, Mayte
Lozano-Ojalvo, Daniel
Cámara, Carmen
del Rosario Llópez-Carratalá, Maria
Gonzalez-Parra, Emilio
Portolés, Pilar
Ortiz, Alberto
Portoles, Jose
Ochando, Jordi
author_facet Gonzalez-Perez, Maria
Baranda, Jana
Berges-Buxeda, Marcos J.
Conde, Patricia
Pérez-Olmeda, Mayte
Lozano-Ojalvo, Daniel
Cámara, Carmen
del Rosario Llópez-Carratalá, Maria
Gonzalez-Parra, Emilio
Portolés, Pilar
Ortiz, Alberto
Portoles, Jose
Ochando, Jordi
author_sort Gonzalez-Perez, Maria
collection PubMed
description Continuous evaluation of the coronavirus disease 2019 (COVID-19) vaccine effectiveness in hemodialysis (HD) patients is critical in this immunocompromised patient group with higher mortality rates due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The response towards vaccination in HD patients has been studied weeks after their first and second SARS-CoV-2 vaccination dose administration, but no further studies have been developed in a long-term manner, especially including both the humoral and cellular immune response. Longitudinal studies that monitor the immune response to COVID-19 vaccination in individuals undergoing HD are therefore necessary to prioritize vaccination strategies and minimize the pathogenic effects of SARS-CoV-2 in this high-risk group of patients. We followed up HD patients and healthy volunteers (HV) and monitored their humoral and cellular immune response three months after the second (V2+3M) and after the third vaccination dose (V3+3M), taking into consideration previous COVID-19 infections. Our cellular immunity results show that, while HD patients and HV individuals secrete comparable levels of IFN-γ and IL-2 in ex vivo stimulated whole blood at V2+3M in both naïve and COVID-19-recovered individuals, HD patients secrete higher levels of IFN-γ and IL-2 than HV at V3+3M. This is mainly due to a decay in the cellular immune response in HV individuals after the third dose. In contrast, our humoral immunity results show similar IgG binding antibody units (BAU) between HD patients and HV individuals at V3+3M, independently of their previous infection status. Overall, our results indicate that HD patients maintain strong cellular and humoral immune responses after repeated 1273-mRNA SARS-CoV-2 vaccinations over time. The data also highlights significant differences between cellular and humoral immunity after SARS-CoV-2 vaccination, which emphasizes the importance of monitoring both arms of the immune response in the immunocompromised population.
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spelling pubmed-101410112023-04-29 Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination Gonzalez-Perez, Maria Baranda, Jana Berges-Buxeda, Marcos J. Conde, Patricia Pérez-Olmeda, Mayte Lozano-Ojalvo, Daniel Cámara, Carmen del Rosario Llópez-Carratalá, Maria Gonzalez-Parra, Emilio Portolés, Pilar Ortiz, Alberto Portoles, Jose Ochando, Jordi Pharmaceuticals (Basel) Communication Continuous evaluation of the coronavirus disease 2019 (COVID-19) vaccine effectiveness in hemodialysis (HD) patients is critical in this immunocompromised patient group with higher mortality rates due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The response towards vaccination in HD patients has been studied weeks after their first and second SARS-CoV-2 vaccination dose administration, but no further studies have been developed in a long-term manner, especially including both the humoral and cellular immune response. Longitudinal studies that monitor the immune response to COVID-19 vaccination in individuals undergoing HD are therefore necessary to prioritize vaccination strategies and minimize the pathogenic effects of SARS-CoV-2 in this high-risk group of patients. We followed up HD patients and healthy volunteers (HV) and monitored their humoral and cellular immune response three months after the second (V2+3M) and after the third vaccination dose (V3+3M), taking into consideration previous COVID-19 infections. Our cellular immunity results show that, while HD patients and HV individuals secrete comparable levels of IFN-γ and IL-2 in ex vivo stimulated whole blood at V2+3M in both naïve and COVID-19-recovered individuals, HD patients secrete higher levels of IFN-γ and IL-2 than HV at V3+3M. This is mainly due to a decay in the cellular immune response in HV individuals after the third dose. In contrast, our humoral immunity results show similar IgG binding antibody units (BAU) between HD patients and HV individuals at V3+3M, independently of their previous infection status. Overall, our results indicate that HD patients maintain strong cellular and humoral immune responses after repeated 1273-mRNA SARS-CoV-2 vaccinations over time. The data also highlights significant differences between cellular and humoral immunity after SARS-CoV-2 vaccination, which emphasizes the importance of monitoring both arms of the immune response in the immunocompromised population. MDPI 2023-04-11 /pmc/articles/PMC10141011/ /pubmed/37111331 http://dx.doi.org/10.3390/ph16040574 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Gonzalez-Perez, Maria
Baranda, Jana
Berges-Buxeda, Marcos J.
Conde, Patricia
Pérez-Olmeda, Mayte
Lozano-Ojalvo, Daniel
Cámara, Carmen
del Rosario Llópez-Carratalá, Maria
Gonzalez-Parra, Emilio
Portolés, Pilar
Ortiz, Alberto
Portoles, Jose
Ochando, Jordi
Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
title Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
title_full Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
title_fullStr Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
title_full_unstemmed Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
title_short Maintenance of Potent Cellular and Humoral Immune Responses in Long-Term Hemodialysis Patients after 1273-mRNA SARS-CoV-2 Vaccination
title_sort maintenance of potent cellular and humoral immune responses in long-term hemodialysis patients after 1273-mrna sars-cov-2 vaccination
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141011/
https://www.ncbi.nlm.nih.gov/pubmed/37111331
http://dx.doi.org/10.3390/ph16040574
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