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pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release?
pH-sensitive liposomes have great potential for biomedical applications, in particular as nanocontainers for the delivery of biologically active compounds to specific areas of the human body. In this article, we discuss the possible mechanism of fast cargo release from a new type of pH-sensitive lip...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141028/ https://www.ncbi.nlm.nih.gov/pubmed/37103834 http://dx.doi.org/10.3390/membranes13040407 |
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author | Efimova, Anna A. Popov, Anton S. Kazantsev, Alexey V. Semenyuk, Pavel I. Le-Deygen, Irina M. Lukashev, Nikolay V. Yaroslavov, Alexander A. |
author_facet | Efimova, Anna A. Popov, Anton S. Kazantsev, Alexey V. Semenyuk, Pavel I. Le-Deygen, Irina M. Lukashev, Nikolay V. Yaroslavov, Alexander A. |
author_sort | Efimova, Anna A. |
collection | PubMed |
description | pH-sensitive liposomes have great potential for biomedical applications, in particular as nanocontainers for the delivery of biologically active compounds to specific areas of the human body. In this article, we discuss the possible mechanism of fast cargo release from a new type of pH-sensitive liposomes with embedded ampholytic molecular switch (AMS, 3-(isobutylamino)cholan-24-oic acid) with carboxylic anionic groups and isobutylamino cationic ones attached to the opposite ends of the steroid core. AMS-containing liposomes demonstrated the rapid release of the encapsulated substance when altering the pH of an outer solution, but the exact mechanism of the switch action has not yet been accurately determined. Here, we report on the details of fast cargo release based on the data obtained using ATR-FTIR spectroscopy as well as atomistic molecular modeling. The findings of this study are relevant to the potential application of AMS-containing pH-sensitive liposomes for drug delivery. |
format | Online Article Text |
id | pubmed-10141028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101410282023-04-29 pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release? Efimova, Anna A. Popov, Anton S. Kazantsev, Alexey V. Semenyuk, Pavel I. Le-Deygen, Irina M. Lukashev, Nikolay V. Yaroslavov, Alexander A. Membranes (Basel) Article pH-sensitive liposomes have great potential for biomedical applications, in particular as nanocontainers for the delivery of biologically active compounds to specific areas of the human body. In this article, we discuss the possible mechanism of fast cargo release from a new type of pH-sensitive liposomes with embedded ampholytic molecular switch (AMS, 3-(isobutylamino)cholan-24-oic acid) with carboxylic anionic groups and isobutylamino cationic ones attached to the opposite ends of the steroid core. AMS-containing liposomes demonstrated the rapid release of the encapsulated substance when altering the pH of an outer solution, but the exact mechanism of the switch action has not yet been accurately determined. Here, we report on the details of fast cargo release based on the data obtained using ATR-FTIR spectroscopy as well as atomistic molecular modeling. The findings of this study are relevant to the potential application of AMS-containing pH-sensitive liposomes for drug delivery. MDPI 2023-04-04 /pmc/articles/PMC10141028/ /pubmed/37103834 http://dx.doi.org/10.3390/membranes13040407 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Efimova, Anna A. Popov, Anton S. Kazantsev, Alexey V. Semenyuk, Pavel I. Le-Deygen, Irina M. Lukashev, Nikolay V. Yaroslavov, Alexander A. pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release? |
title | pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release? |
title_full | pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release? |
title_fullStr | pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release? |
title_full_unstemmed | pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release? |
title_short | pH-Sensitive Liposomes with Embedded 3-(isobutylamino)cholan-24-oic Acid: What Is the Possible Mechanism of Fast Cargo Release? |
title_sort | ph-sensitive liposomes with embedded 3-(isobutylamino)cholan-24-oic acid: what is the possible mechanism of fast cargo release? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141028/ https://www.ncbi.nlm.nih.gov/pubmed/37103834 http://dx.doi.org/10.3390/membranes13040407 |
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