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4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers

Objectives: Four-dimensional (4D) flow cardiac magnetic resonance (CMR) represents an emerging technique for non-invasive evaluation of the aortic flow. The aim of this study was to investigate a 4D-flow CMR sequence for the assessment of thoracic aorta comparing different vendors and different magn...

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Autores principales: Punzo, Bruna, Ranieri, Brigida, Tramontano, Liberatore, Affinito, Ornella, Franzese, Monica, Bossone, Eduardo, Saba, Luca, Cavaliere, Carlo, Cademartiri, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141060/
https://www.ncbi.nlm.nih.gov/pubmed/37109295
http://dx.doi.org/10.3390/jcm12082960
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author Punzo, Bruna
Ranieri, Brigida
Tramontano, Liberatore
Affinito, Ornella
Franzese, Monica
Bossone, Eduardo
Saba, Luca
Cavaliere, Carlo
Cademartiri, Filippo
author_facet Punzo, Bruna
Ranieri, Brigida
Tramontano, Liberatore
Affinito, Ornella
Franzese, Monica
Bossone, Eduardo
Saba, Luca
Cavaliere, Carlo
Cademartiri, Filippo
author_sort Punzo, Bruna
collection PubMed
description Objectives: Four-dimensional (4D) flow cardiac magnetic resonance (CMR) represents an emerging technique for non-invasive evaluation of the aortic flow. The aim of this study was to investigate a 4D-flow CMR sequence for the assessment of thoracic aorta comparing different vendors and different magnetic fields of MR scanner in fifteen healthy volunteers. Methods: CMR was performed on three different MRI scanners: one at 1.5 T and two at 3 T. Flow parameters and planar wall shear stress (WSS) were extracted from six transversal planes along the full thoracic aorta by three operators. Inter-vendor comparability as well as scan–rescan, intra- and interobserver reproducibility were examined. Results: A high heterogeneity was found in the comparisons for each operator and for each scanner in the six transversal planes analysis (Friedman rank-sum test; p-value ≤ 0.05). Among all, the most reproducible measures were extracted for the sinotubular junction plane and for the flow parameters. Conclusions: Our results suggest that standardized procedures have to be defined to make more comparable and reproducible 4D-flow parameters and mainly, clinical impactfulness. Further studies on sequences development are needed to validate 4D-flow MRI assessment across vendors and magnetic fields also compared to a missing gold standard.
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spelling pubmed-101410602023-04-29 4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers Punzo, Bruna Ranieri, Brigida Tramontano, Liberatore Affinito, Ornella Franzese, Monica Bossone, Eduardo Saba, Luca Cavaliere, Carlo Cademartiri, Filippo J Clin Med Article Objectives: Four-dimensional (4D) flow cardiac magnetic resonance (CMR) represents an emerging technique for non-invasive evaluation of the aortic flow. The aim of this study was to investigate a 4D-flow CMR sequence for the assessment of thoracic aorta comparing different vendors and different magnetic fields of MR scanner in fifteen healthy volunteers. Methods: CMR was performed on three different MRI scanners: one at 1.5 T and two at 3 T. Flow parameters and planar wall shear stress (WSS) were extracted from six transversal planes along the full thoracic aorta by three operators. Inter-vendor comparability as well as scan–rescan, intra- and interobserver reproducibility were examined. Results: A high heterogeneity was found in the comparisons for each operator and for each scanner in the six transversal planes analysis (Friedman rank-sum test; p-value ≤ 0.05). Among all, the most reproducible measures were extracted for the sinotubular junction plane and for the flow parameters. Conclusions: Our results suggest that standardized procedures have to be defined to make more comparable and reproducible 4D-flow parameters and mainly, clinical impactfulness. Further studies on sequences development are needed to validate 4D-flow MRI assessment across vendors and magnetic fields also compared to a missing gold standard. MDPI 2023-04-19 /pmc/articles/PMC10141060/ /pubmed/37109295 http://dx.doi.org/10.3390/jcm12082960 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Punzo, Bruna
Ranieri, Brigida
Tramontano, Liberatore
Affinito, Ornella
Franzese, Monica
Bossone, Eduardo
Saba, Luca
Cavaliere, Carlo
Cademartiri, Filippo
4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers
title 4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers
title_full 4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers
title_fullStr 4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers
title_full_unstemmed 4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers
title_short 4D-Flow Cardiovascular Magnetic Resonance Sequence for Aortic Assessment: Multi-Vendor and Multi-Magnetic Field Reproducibility in Healthy Volunteers
title_sort 4d-flow cardiovascular magnetic resonance sequence for aortic assessment: multi-vendor and multi-magnetic field reproducibility in healthy volunteers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141060/
https://www.ncbi.nlm.nih.gov/pubmed/37109295
http://dx.doi.org/10.3390/jcm12082960
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