Cargando…

Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances

The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal speci...

Descripción completa

Detalles Bibliográficos
Autores principales: Suda, Takeshi, Yokoo, Takeshi, Kanefuji, Tsutomu, Kamimura, Kenya, Zhang, Guisheng, Liu, Dexi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141091/
https://www.ncbi.nlm.nih.gov/pubmed/37111597
http://dx.doi.org/10.3390/pharmaceutics15041111
_version_ 1785033309534814208
author Suda, Takeshi
Yokoo, Takeshi
Kanefuji, Tsutomu
Kamimura, Kenya
Zhang, Guisheng
Liu, Dexi
author_facet Suda, Takeshi
Yokoo, Takeshi
Kanefuji, Tsutomu
Kamimura, Kenya
Zhang, Guisheng
Liu, Dexi
author_sort Suda, Takeshi
collection PubMed
description The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal species through systemic or local injection, resulting in significant advances in new applications and technological development. The development of regional hydrodynamic delivery directly supports successful gene delivery in large animals, including humans. This review summarizes the fundamentals of hydrodynamic delivery and the progress that has been made in its application. Recent progress in this field offers tantalizing prospects for the development of a new generation of technologies for broader application of hydrodynamic delivery.
format Online
Article
Text
id pubmed-10141091
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-101410912023-04-29 Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances Suda, Takeshi Yokoo, Takeshi Kanefuji, Tsutomu Kamimura, Kenya Zhang, Guisheng Liu, Dexi Pharmaceutics Review The principle of hydrodynamic delivery was initially used to develop a method for the delivery of plasmids into mouse hepatocytes through tail vein injection and has been expanded for use in the delivery of various biologically active materials to cells in various organs in a variety of animal species through systemic or local injection, resulting in significant advances in new applications and technological development. The development of regional hydrodynamic delivery directly supports successful gene delivery in large animals, including humans. This review summarizes the fundamentals of hydrodynamic delivery and the progress that has been made in its application. Recent progress in this field offers tantalizing prospects for the development of a new generation of technologies for broader application of hydrodynamic delivery. MDPI 2023-03-31 /pmc/articles/PMC10141091/ /pubmed/37111597 http://dx.doi.org/10.3390/pharmaceutics15041111 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Suda, Takeshi
Yokoo, Takeshi
Kanefuji, Tsutomu
Kamimura, Kenya
Zhang, Guisheng
Liu, Dexi
Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances
title Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances
title_full Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances
title_fullStr Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances
title_full_unstemmed Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances
title_short Hydrodynamic Delivery: Characteristics, Applications, and Technological Advances
title_sort hydrodynamic delivery: characteristics, applications, and technological advances
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141091/
https://www.ncbi.nlm.nih.gov/pubmed/37111597
http://dx.doi.org/10.3390/pharmaceutics15041111
work_keys_str_mv AT sudatakeshi hydrodynamicdeliverycharacteristicsapplicationsandtechnologicaladvances
AT yokootakeshi hydrodynamicdeliverycharacteristicsapplicationsandtechnologicaladvances
AT kanefujitsutomu hydrodynamicdeliverycharacteristicsapplicationsandtechnologicaladvances
AT kamimurakenya hydrodynamicdeliverycharacteristicsapplicationsandtechnologicaladvances
AT zhangguisheng hydrodynamicdeliverycharacteristicsapplicationsandtechnologicaladvances
AT liudexi hydrodynamicdeliverycharacteristicsapplicationsandtechnologicaladvances