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Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures

Cutaneous melanoma (CM) remains one of the leading causes of tumor mortality due to its high metastatic spread. CM growth is influenced by inflammation regulated by prostaglandins (PGs) whose synthesis is catalyzed by cyclooxygenases (COXs). COX inhibitors, including non-steroidal anti-inflammatory...

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Autores principales: Venuta, Alessandro, Nasso, Rosarita, Gisonna, Armando, Iuliano, Roberta, Montesarchio, Sara, Acampora, Vittoria, Sepe, Leandra, Avagliano, Angelica, Arcone, Rosaria, Arcucci, Alessandro, Ruocco, Maria Rosaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141119/
https://www.ncbi.nlm.nih.gov/pubmed/37109596
http://dx.doi.org/10.3390/life13041067
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author Venuta, Alessandro
Nasso, Rosarita
Gisonna, Armando
Iuliano, Roberta
Montesarchio, Sara
Acampora, Vittoria
Sepe, Leandra
Avagliano, Angelica
Arcone, Rosaria
Arcucci, Alessandro
Ruocco, Maria Rosaria
author_facet Venuta, Alessandro
Nasso, Rosarita
Gisonna, Armando
Iuliano, Roberta
Montesarchio, Sara
Acampora, Vittoria
Sepe, Leandra
Avagliano, Angelica
Arcone, Rosaria
Arcucci, Alessandro
Ruocco, Maria Rosaria
author_sort Venuta, Alessandro
collection PubMed
description Cutaneous melanoma (CM) remains one of the leading causes of tumor mortality due to its high metastatic spread. CM growth is influenced by inflammation regulated by prostaglandins (PGs) whose synthesis is catalyzed by cyclooxygenases (COXs). COX inhibitors, including non-steroidal anti-inflammatory drugs (NSAIDs), can inhibit tumor development and growth. In particular, in vitro experiments have shown that celecoxib, a NSAID, inhibits the growth of some tumor cell lines. However, two-dimensional (2D) cell cultures, used in traditional in vitro anticancer assays, often show poor efficacy due to a lack of an in vivo like cellular environment. Three-dimensional (3D) cell cultures, such as spheroids, are better models because they can mimic the common features displayed by human solid tumors. Hence, in this study, we evaluated the anti-neoplastic potential of celecoxib, in both 2D and 3D cell cultures of A2058 and SAN melanoma cell lines. In particular, celecoxib reduced the cell viability and migratory capability and triggered the apoptosis of melanoma cells grown as 2D cultures. When celecoxib was tested on 3D melanoma cell cultures, the drug exerted an inhibitory effect on cell outgrowth from spheroids and reduced the invasiveness of melanoma cell spheroids into the hydrogel matrix. This work suggests that celecoxib could represent a new potential therapeutic approach in melanoma therapy.
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spelling pubmed-101411192023-04-29 Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures Venuta, Alessandro Nasso, Rosarita Gisonna, Armando Iuliano, Roberta Montesarchio, Sara Acampora, Vittoria Sepe, Leandra Avagliano, Angelica Arcone, Rosaria Arcucci, Alessandro Ruocco, Maria Rosaria Life (Basel) Article Cutaneous melanoma (CM) remains one of the leading causes of tumor mortality due to its high metastatic spread. CM growth is influenced by inflammation regulated by prostaglandins (PGs) whose synthesis is catalyzed by cyclooxygenases (COXs). COX inhibitors, including non-steroidal anti-inflammatory drugs (NSAIDs), can inhibit tumor development and growth. In particular, in vitro experiments have shown that celecoxib, a NSAID, inhibits the growth of some tumor cell lines. However, two-dimensional (2D) cell cultures, used in traditional in vitro anticancer assays, often show poor efficacy due to a lack of an in vivo like cellular environment. Three-dimensional (3D) cell cultures, such as spheroids, are better models because they can mimic the common features displayed by human solid tumors. Hence, in this study, we evaluated the anti-neoplastic potential of celecoxib, in both 2D and 3D cell cultures of A2058 and SAN melanoma cell lines. In particular, celecoxib reduced the cell viability and migratory capability and triggered the apoptosis of melanoma cells grown as 2D cultures. When celecoxib was tested on 3D melanoma cell cultures, the drug exerted an inhibitory effect on cell outgrowth from spheroids and reduced the invasiveness of melanoma cell spheroids into the hydrogel matrix. This work suggests that celecoxib could represent a new potential therapeutic approach in melanoma therapy. MDPI 2023-04-21 /pmc/articles/PMC10141119/ /pubmed/37109596 http://dx.doi.org/10.3390/life13041067 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Venuta, Alessandro
Nasso, Rosarita
Gisonna, Armando
Iuliano, Roberta
Montesarchio, Sara
Acampora, Vittoria
Sepe, Leandra
Avagliano, Angelica
Arcone, Rosaria
Arcucci, Alessandro
Ruocco, Maria Rosaria
Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures
title Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures
title_full Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures
title_fullStr Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures
title_full_unstemmed Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures
title_short Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures
title_sort celecoxib, a non-steroidal anti-inflammatory drug, exerts a toxic effect on human melanoma cells grown as 2d and 3d cell cultures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141119/
https://www.ncbi.nlm.nih.gov/pubmed/37109596
http://dx.doi.org/10.3390/life13041067
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