Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase

[Image: see text] Modular polyketide synthases (PKSs) are polymerases that employ α-carboxyacyl-CoAs as extender substrates. This enzyme family contains several catalytic modules, where each module is responsible for a single round of polyketide chain extension. Although PKS modules typically use ma...

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Detalles Bibliográficos
Autores principales: Englund, Elias, Schmidt, Matthias, Nava, Alberto A., Lechner, Anna, Deng, Kai, Jocic, Renee, Lin, Yingxin, Roberts, Jacob, Benites, Veronica T., Kakumanu, Ramu, Gin, Jennifer W., Chen, Yan, Liu, Yuzhong, Petzold, Christopher J., Baidoo, Edward E. K., Northen, Trent R., Adams, Paul D., Katz, Leonard, Yuzawa, Satoshi, Keasling, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141241/
https://www.ncbi.nlm.nih.gov/pubmed/37057992
http://dx.doi.org/10.1021/jacs.2c11027

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