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Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials
[Image: see text] We present the concept of a versatile drug-loaded composite hydrogel that can be activated using an argon-based cold atmospheric plasma (CAP) jet to deliver both a drug and CAP-generated molecules, concomitantly, in a tissue target. To demonstrate this concept, we utilized the anti...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141252/ https://www.ncbi.nlm.nih.gov/pubmed/37040527 http://dx.doi.org/10.1021/acsami.3c01208 |
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author | Gaur, Nishtha Patenall, Bethany L. Ghimire, Bhagirath Thet, Naing T. Gardiner, Jordan E. Le Doare, Krystal E. Ramage, Gordon Short, Bryn Heylen, Rachel A. Williams, Craig Short, Robert D. Jenkins, Toby A. |
author_facet | Gaur, Nishtha Patenall, Bethany L. Ghimire, Bhagirath Thet, Naing T. Gardiner, Jordan E. Le Doare, Krystal E. Ramage, Gordon Short, Bryn Heylen, Rachel A. Williams, Craig Short, Robert D. Jenkins, Toby A. |
author_sort | Gaur, Nishtha |
collection | PubMed |
description | [Image: see text] We present the concept of a versatile drug-loaded composite hydrogel that can be activated using an argon-based cold atmospheric plasma (CAP) jet to deliver both a drug and CAP-generated molecules, concomitantly, in a tissue target. To demonstrate this concept, we utilized the antibiotic gentamicin that is encapsulated in sodium polyacrylate (PAA) particles, which are dispersed within a poly(vinyl alcohol) (PVA) hydrogel matrix. The final product is a gentamicin-PAA-PVA composite hydrogel suitable for an on-demand triggered release using CAP. We show that by activating using CAP, we can effectively release gentamicin from the hydrogel and also eradicate the bacteria effectively, both in the planktonic state and within a biofilm. Besides gentamicin, we also successfully demonstrate the applicability of the CAP-activated composite hydrogel loaded with other antimicrobial agents such as cetrimide and silver. This concept of a composite hydrogel is potentially adaptable to a range of therapeutics (such as antimicrobials, anticancer agents, and nanoparticles) and activatable using any dielectric barrier discharge CAP device. |
format | Online Article Text |
id | pubmed-10141252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-101412522023-04-29 Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials Gaur, Nishtha Patenall, Bethany L. Ghimire, Bhagirath Thet, Naing T. Gardiner, Jordan E. Le Doare, Krystal E. Ramage, Gordon Short, Bryn Heylen, Rachel A. Williams, Craig Short, Robert D. Jenkins, Toby A. ACS Appl Mater Interfaces [Image: see text] We present the concept of a versatile drug-loaded composite hydrogel that can be activated using an argon-based cold atmospheric plasma (CAP) jet to deliver both a drug and CAP-generated molecules, concomitantly, in a tissue target. To demonstrate this concept, we utilized the antibiotic gentamicin that is encapsulated in sodium polyacrylate (PAA) particles, which are dispersed within a poly(vinyl alcohol) (PVA) hydrogel matrix. The final product is a gentamicin-PAA-PVA composite hydrogel suitable for an on-demand triggered release using CAP. We show that by activating using CAP, we can effectively release gentamicin from the hydrogel and also eradicate the bacteria effectively, both in the planktonic state and within a biofilm. Besides gentamicin, we also successfully demonstrate the applicability of the CAP-activated composite hydrogel loaded with other antimicrobial agents such as cetrimide and silver. This concept of a composite hydrogel is potentially adaptable to a range of therapeutics (such as antimicrobials, anticancer agents, and nanoparticles) and activatable using any dielectric barrier discharge CAP device. American Chemical Society 2023-04-11 /pmc/articles/PMC10141252/ /pubmed/37040527 http://dx.doi.org/10.1021/acsami.3c01208 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Gaur, Nishtha Patenall, Bethany L. Ghimire, Bhagirath Thet, Naing T. Gardiner, Jordan E. Le Doare, Krystal E. Ramage, Gordon Short, Bryn Heylen, Rachel A. Williams, Craig Short, Robert D. Jenkins, Toby A. Cold Atmospheric Plasma-Activated Composite Hydrogel for an Enhanced and On-Demand Delivery of Antimicrobials |
title | Cold Atmospheric
Plasma-Activated Composite Hydrogel
for an Enhanced and On-Demand Delivery of Antimicrobials |
title_full | Cold Atmospheric
Plasma-Activated Composite Hydrogel
for an Enhanced and On-Demand Delivery of Antimicrobials |
title_fullStr | Cold Atmospheric
Plasma-Activated Composite Hydrogel
for an Enhanced and On-Demand Delivery of Antimicrobials |
title_full_unstemmed | Cold Atmospheric
Plasma-Activated Composite Hydrogel
for an Enhanced and On-Demand Delivery of Antimicrobials |
title_short | Cold Atmospheric
Plasma-Activated Composite Hydrogel
for an Enhanced and On-Demand Delivery of Antimicrobials |
title_sort | cold atmospheric
plasma-activated composite hydrogel
for an enhanced and on-demand delivery of antimicrobials |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141252/ https://www.ncbi.nlm.nih.gov/pubmed/37040527 http://dx.doi.org/10.1021/acsami.3c01208 |
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