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Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method
Dispersive liquid–liquid microextraction (DLLME) combined with ultra-high performance liquid chromatography-diode array detector (UHPLC-DAD) method has been developed and validated for the determination of parabens in personal care products. In this study, a natural deep eutectic solvent (NADES) com...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141287/ https://www.ncbi.nlm.nih.gov/pubmed/37124025 http://dx.doi.org/10.1039/d3ra00769c |
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author | Alqarni, Abdulmalik M. Mostafa, Ahmed Shaaban, Heba Gomaa, Mohamed S. Albashrayi, Danyah Hasheeshi, Batool Bakhashwain, Nujud Aseeri, Atheer Alqarni, Abdulaziz Alamri, Abdulgani A. Alrofaidi, Mohammad A. |
author_facet | Alqarni, Abdulmalik M. Mostafa, Ahmed Shaaban, Heba Gomaa, Mohamed S. Albashrayi, Danyah Hasheeshi, Batool Bakhashwain, Nujud Aseeri, Atheer Alqarni, Abdulaziz Alamri, Abdulgani A. Alrofaidi, Mohammad A. |
author_sort | Alqarni, Abdulmalik M. |
collection | PubMed |
description | Dispersive liquid–liquid microextraction (DLLME) combined with ultra-high performance liquid chromatography-diode array detector (UHPLC-DAD) method has been developed and validated for the determination of parabens in personal care products. In this study, a natural deep eutectic solvent (NADES) composed of menthol and formic acid at a molar ratio of 1 : 2 was prepared and used as an extraction solvent. The influencing variables on the extraction efficiency such as extraction solvent type and volume, composition of NADES, salt addition, vortex and centrifugation time were investigated. The proposed method exhibited good linearity with determination coefficients of ≥0.9992. The relative recoveries for the studied analytes ranged from 82.19 to 102.45%. Limits of detection and limits of quantification were in the range of 0.17–0.33 ng mL(−1) and 0.51–0.99 ng mL(−1), respectively. To evaluate the applicability of the developed method, it was successfully applied to determine four parabens in personal care products. Additionally, the eco-friendliness level of the presented method was evaluated using Eco-Scale Assessment, Green Analytical Procedure Index and Analytical GREEnness metric. The developed method is simple, environmentally friendly and cost effective and it could be employed for determination of parabens in personal care products without harming the environment. |
format | Online Article Text |
id | pubmed-10141287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-101412872023-04-29 Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method Alqarni, Abdulmalik M. Mostafa, Ahmed Shaaban, Heba Gomaa, Mohamed S. Albashrayi, Danyah Hasheeshi, Batool Bakhashwain, Nujud Aseeri, Atheer Alqarni, Abdulaziz Alamri, Abdulgani A. Alrofaidi, Mohammad A. RSC Adv Chemistry Dispersive liquid–liquid microextraction (DLLME) combined with ultra-high performance liquid chromatography-diode array detector (UHPLC-DAD) method has been developed and validated for the determination of parabens in personal care products. In this study, a natural deep eutectic solvent (NADES) composed of menthol and formic acid at a molar ratio of 1 : 2 was prepared and used as an extraction solvent. The influencing variables on the extraction efficiency such as extraction solvent type and volume, composition of NADES, salt addition, vortex and centrifugation time were investigated. The proposed method exhibited good linearity with determination coefficients of ≥0.9992. The relative recoveries for the studied analytes ranged from 82.19 to 102.45%. Limits of detection and limits of quantification were in the range of 0.17–0.33 ng mL(−1) and 0.51–0.99 ng mL(−1), respectively. To evaluate the applicability of the developed method, it was successfully applied to determine four parabens in personal care products. Additionally, the eco-friendliness level of the presented method was evaluated using Eco-Scale Assessment, Green Analytical Procedure Index and Analytical GREEnness metric. The developed method is simple, environmentally friendly and cost effective and it could be employed for determination of parabens in personal care products without harming the environment. The Royal Society of Chemistry 2023-04-28 /pmc/articles/PMC10141287/ /pubmed/37124025 http://dx.doi.org/10.1039/d3ra00769c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Alqarni, Abdulmalik M. Mostafa, Ahmed Shaaban, Heba Gomaa, Mohamed S. Albashrayi, Danyah Hasheeshi, Batool Bakhashwain, Nujud Aseeri, Atheer Alqarni, Abdulaziz Alamri, Abdulgani A. Alrofaidi, Mohammad A. Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method |
title | Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method |
title_full | Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method |
title_fullStr | Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method |
title_full_unstemmed | Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method |
title_short | Development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with UPLC-UV for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method |
title_sort | development and optimization of natural deep eutectic solvent-based dispersive liquid–liquid microextraction coupled with uplc-uv for simultaneous determination of parabens in personal care products: evaluation of the eco-friendliness level of the developed method |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141287/ https://www.ncbi.nlm.nih.gov/pubmed/37124025 http://dx.doi.org/10.1039/d3ra00769c |
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