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Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems

Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since their discovery and are a powerful weapon in the fight against bacteria. However, with the widespread use of antibiotics, the problem of drug resistance now poses a great threat to human health. In recent...

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Autores principales: Yao, Jiaxin, Zou, Pengfei, Cui, Yanan, Quan, Liangzhu, Gao, Chunsheng, Li, Zhiping, Gong, Wei, Yang, Meiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141387/
https://www.ncbi.nlm.nih.gov/pubmed/37111673
http://dx.doi.org/10.3390/pharmaceutics15041188
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author Yao, Jiaxin
Zou, Pengfei
Cui, Yanan
Quan, Liangzhu
Gao, Chunsheng
Li, Zhiping
Gong, Wei
Yang, Meiyan
author_facet Yao, Jiaxin
Zou, Pengfei
Cui, Yanan
Quan, Liangzhu
Gao, Chunsheng
Li, Zhiping
Gong, Wei
Yang, Meiyan
author_sort Yao, Jiaxin
collection PubMed
description Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since their discovery and are a powerful weapon in the fight against bacteria. However, with the widespread use of antibiotics, the problem of drug resistance now poses a great threat to human health. In recent years, studies have investigated approaches to combat bacterial resistance. Several antimicrobial materials and drug delivery systems have emerged as promising strategies. Nano-drug delivery systems for antibiotics can reduce the resistance to antibiotics and extend the lifespan of novel antibiotics, and they allow targeting drug delivery compared to conventional antibiotics. This review highlights the mechanistic insights of using different strategies to combat drug-resistant bacteria and summarizes the recent advancements in antimicrobial materials and drug delivery systems for different carriers. Furthermore, the fundamental properties of combating antimicrobial resistance are discussed, and the current challenges and future perspectives in this field are proposed.
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spelling pubmed-101413872023-04-29 Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems Yao, Jiaxin Zou, Pengfei Cui, Yanan Quan, Liangzhu Gao, Chunsheng Li, Zhiping Gong, Wei Yang, Meiyan Pharmaceutics Review Bacterial infection is a common clinical disease. Antibiotics have saved countless lives since their discovery and are a powerful weapon in the fight against bacteria. However, with the widespread use of antibiotics, the problem of drug resistance now poses a great threat to human health. In recent years, studies have investigated approaches to combat bacterial resistance. Several antimicrobial materials and drug delivery systems have emerged as promising strategies. Nano-drug delivery systems for antibiotics can reduce the resistance to antibiotics and extend the lifespan of novel antibiotics, and they allow targeting drug delivery compared to conventional antibiotics. This review highlights the mechanistic insights of using different strategies to combat drug-resistant bacteria and summarizes the recent advancements in antimicrobial materials and drug delivery systems for different carriers. Furthermore, the fundamental properties of combating antimicrobial resistance are discussed, and the current challenges and future perspectives in this field are proposed. MDPI 2023-04-07 /pmc/articles/PMC10141387/ /pubmed/37111673 http://dx.doi.org/10.3390/pharmaceutics15041188 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yao, Jiaxin
Zou, Pengfei
Cui, Yanan
Quan, Liangzhu
Gao, Chunsheng
Li, Zhiping
Gong, Wei
Yang, Meiyan
Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems
title Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems
title_full Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems
title_fullStr Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems
title_full_unstemmed Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems
title_short Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems
title_sort recent advances in strategies to combat bacterial drug resistance: antimicrobial materials and drug delivery systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141387/
https://www.ncbi.nlm.nih.gov/pubmed/37111673
http://dx.doi.org/10.3390/pharmaceutics15041188
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