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Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection

Coxiella burnetii is one of the most common causes of blood culture-negative infective endocarditis (IE). However, only a few cases of cardiac implantable electronic devices (CIED) infection have been reported in the literature. Herein, we present a case of CIED-related blood culture-negative infect...

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Autores principales: Papakonstantinou, Panteleimon E., Georgiadou, Victoria, Doumanis, Grigorios, Bistola, Vasiliki, Papaparaskevas, Joseph, Filippatos, Gerasimos, Xydonas, Sotirios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141394/
https://www.ncbi.nlm.nih.gov/pubmed/37109154
http://dx.doi.org/10.3390/jcm12082817
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author Papakonstantinou, Panteleimon E.
Georgiadou, Victoria
Doumanis, Grigorios
Bistola, Vasiliki
Papaparaskevas, Joseph
Filippatos, Gerasimos
Xydonas, Sotirios
author_facet Papakonstantinou, Panteleimon E.
Georgiadou, Victoria
Doumanis, Grigorios
Bistola, Vasiliki
Papaparaskevas, Joseph
Filippatos, Gerasimos
Xydonas, Sotirios
author_sort Papakonstantinou, Panteleimon E.
collection PubMed
description Coxiella burnetii is one of the most common causes of blood culture-negative infective endocarditis (IE). However, only a few cases of cardiac implantable electronic devices (CIED) infection have been reported in the literature. Herein, we present a case of CIED-related blood culture-negative infection attributed to C. burnetii. A 54-year-old male was admitted to our hospital due to prolonged fatigue, a low-grade fever lasting more than a month, and weight loss. Three years ago, he received an implantable cardiac defibrillator (ICD) as a primary prevention measure against sudden cardiac death. An initial transthoracic and transesophageal echocardiography showed a dilated left ventricle with severely impaired systolic function, while the ventricular pacing wire was inside the right ventricle with a large echogenic mass (2.2 × 2.5 cm) adherent to it. Repeated blood cultures were negative. The patient underwent transvenous lead extraction. A transesophageal echocardiography after the extraction revealed multiple vegetations on the tricuspid valve with moderate to severe valve regurgitation. A surgical replacement of the tricuspid valve was determined after a multidisciplinary heart team approach. Serology tests showed increased IgG antibodies in phase I (1:16,394) and phase II (1:8192), and a definite diagnosis of CIED infection was made based on the serological tests.
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spelling pubmed-101413942023-04-29 Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection Papakonstantinou, Panteleimon E. Georgiadou, Victoria Doumanis, Grigorios Bistola, Vasiliki Papaparaskevas, Joseph Filippatos, Gerasimos Xydonas, Sotirios J Clin Med Case Report Coxiella burnetii is one of the most common causes of blood culture-negative infective endocarditis (IE). However, only a few cases of cardiac implantable electronic devices (CIED) infection have been reported in the literature. Herein, we present a case of CIED-related blood culture-negative infection attributed to C. burnetii. A 54-year-old male was admitted to our hospital due to prolonged fatigue, a low-grade fever lasting more than a month, and weight loss. Three years ago, he received an implantable cardiac defibrillator (ICD) as a primary prevention measure against sudden cardiac death. An initial transthoracic and transesophageal echocardiography showed a dilated left ventricle with severely impaired systolic function, while the ventricular pacing wire was inside the right ventricle with a large echogenic mass (2.2 × 2.5 cm) adherent to it. Repeated blood cultures were negative. The patient underwent transvenous lead extraction. A transesophageal echocardiography after the extraction revealed multiple vegetations on the tricuspid valve with moderate to severe valve regurgitation. A surgical replacement of the tricuspid valve was determined after a multidisciplinary heart team approach. Serology tests showed increased IgG antibodies in phase I (1:16,394) and phase II (1:8192), and a definite diagnosis of CIED infection was made based on the serological tests. MDPI 2023-04-11 /pmc/articles/PMC10141394/ /pubmed/37109154 http://dx.doi.org/10.3390/jcm12082817 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Papakonstantinou, Panteleimon E.
Georgiadou, Victoria
Doumanis, Grigorios
Bistola, Vasiliki
Papaparaskevas, Joseph
Filippatos, Gerasimos
Xydonas, Sotirios
Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection
title Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection
title_full Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection
title_fullStr Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection
title_full_unstemmed Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection
title_short Implantable Cardiac Defibrillator-Related Culture-Negative Infection: A Case of Coxiella burnetii Infection
title_sort implantable cardiac defibrillator-related culture-negative infection: a case of coxiella burnetii infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141394/
https://www.ncbi.nlm.nih.gov/pubmed/37109154
http://dx.doi.org/10.3390/jcm12082817
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