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Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease
In 15–20% of cases, Graves’ disease (GD) shifts to Hashimoto’s thyroiditis (HT), while the shift from HT to GD is rare. We present a case of a patient in whom HT shifted to GD, along with a literature review. A 50-year-old woman with myxedema was diagnosed with Hashimoto’s disease due to hypothyroid...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141468/ https://www.ncbi.nlm.nih.gov/pubmed/37109715 http://dx.doi.org/10.3390/medicina59040757 |
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author | Daramjav, Narantsatsral Takagi, Junko Iwayama, Hideyuki Uchino, Kaori Inukai, Daisuke Otake, Kazuo Ogawa, Tetsuya Takami, Akiyoshi |
author_facet | Daramjav, Narantsatsral Takagi, Junko Iwayama, Hideyuki Uchino, Kaori Inukai, Daisuke Otake, Kazuo Ogawa, Tetsuya Takami, Akiyoshi |
author_sort | Daramjav, Narantsatsral |
collection | PubMed |
description | In 15–20% of cases, Graves’ disease (GD) shifts to Hashimoto’s thyroiditis (HT), while the shift from HT to GD is rare. We present a case of a patient in whom HT shifted to GD, along with a literature review. A 50-year-old woman with myxedema was diagnosed with Hashimoto’s disease due to hypothyroidism and the presence of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb); she also had thyroid stimulating antibodies (TSAb) without any signs of GD. Although thyroid hormone replacement therapy improved her thyroid function, 2 months later, hyperthyroidism appeared and did not improve after discontinuation of the replacement therapy. The patient was diagnosed with GD, which improved with antithyroid agent administration. To date, only 50 cases regarding conversion from HT to GD have been reported. The median age is 44 years (range, 23–82 years), and the median time of conversion is 7 years (range, 0.1–27 years). The male-to-female ratio of HT conversion to GD is 1:9, closer to that of regular GD (1:10) than that of general HT (1:18). All patients received thyroid hormone replacement therapy for hypothyroidism due to HT. Continuous evaluation of TSAb levels is recommended in HT, particularly in cases of TSAb-positive and those under replacement, since it may help predict conversion to GD. Evaluating the clinical characteristics of patients with HT preceding GD is crucial to ensure appropriate treatment and reduce the risk of adverse events. |
format | Online Article Text |
id | pubmed-10141468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101414682023-04-29 Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease Daramjav, Narantsatsral Takagi, Junko Iwayama, Hideyuki Uchino, Kaori Inukai, Daisuke Otake, Kazuo Ogawa, Tetsuya Takami, Akiyoshi Medicina (Kaunas) Case Report In 15–20% of cases, Graves’ disease (GD) shifts to Hashimoto’s thyroiditis (HT), while the shift from HT to GD is rare. We present a case of a patient in whom HT shifted to GD, along with a literature review. A 50-year-old woman with myxedema was diagnosed with Hashimoto’s disease due to hypothyroidism and the presence of antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TgAb); she also had thyroid stimulating antibodies (TSAb) without any signs of GD. Although thyroid hormone replacement therapy improved her thyroid function, 2 months later, hyperthyroidism appeared and did not improve after discontinuation of the replacement therapy. The patient was diagnosed with GD, which improved with antithyroid agent administration. To date, only 50 cases regarding conversion from HT to GD have been reported. The median age is 44 years (range, 23–82 years), and the median time of conversion is 7 years (range, 0.1–27 years). The male-to-female ratio of HT conversion to GD is 1:9, closer to that of regular GD (1:10) than that of general HT (1:18). All patients received thyroid hormone replacement therapy for hypothyroidism due to HT. Continuous evaluation of TSAb levels is recommended in HT, particularly in cases of TSAb-positive and those under replacement, since it may help predict conversion to GD. Evaluating the clinical characteristics of patients with HT preceding GD is crucial to ensure appropriate treatment and reduce the risk of adverse events. MDPI 2023-04-13 /pmc/articles/PMC10141468/ /pubmed/37109715 http://dx.doi.org/10.3390/medicina59040757 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Daramjav, Narantsatsral Takagi, Junko Iwayama, Hideyuki Uchino, Kaori Inukai, Daisuke Otake, Kazuo Ogawa, Tetsuya Takami, Akiyoshi Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease |
title | Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease |
title_full | Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease |
title_fullStr | Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease |
title_full_unstemmed | Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease |
title_short | Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease |
title_sort | autoimmune thyroiditis shifting from hashimoto’s thyroiditis to graves’ disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141468/ https://www.ncbi.nlm.nih.gov/pubmed/37109715 http://dx.doi.org/10.3390/medicina59040757 |
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