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Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies f...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141492/ https://www.ncbi.nlm.nih.gov/pubmed/37111244 http://dx.doi.org/10.3390/ph16040487 |
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author | Assadpour, Elham Rezaei, Atefe Das, Sabya Sachi Krishna Rao, Balaga Venkata Singh, Sandeep Kumar Kharazmi, Mohammad Saeed Jha, Niraj Kumar Jha, Saurabh Kumar Prieto, Miguel A. Jafari, Seid Mahdi |
author_facet | Assadpour, Elham Rezaei, Atefe Das, Sabya Sachi Krishna Rao, Balaga Venkata Singh, Sandeep Kumar Kharazmi, Mohammad Saeed Jha, Niraj Kumar Jha, Saurabh Kumar Prieto, Miguel A. Jafari, Seid Mahdi |
author_sort | Assadpour, Elham |
collection | PubMed |
description | Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD. |
format | Online Article Text |
id | pubmed-10141492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101414922023-04-29 Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications Assadpour, Elham Rezaei, Atefe Das, Sabya Sachi Krishna Rao, Balaga Venkata Singh, Sandeep Kumar Kharazmi, Mohammad Saeed Jha, Niraj Kumar Jha, Saurabh Kumar Prieto, Miguel A. Jafari, Seid Mahdi Pharmaceuticals (Basel) Review Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD. MDPI 2023-03-24 /pmc/articles/PMC10141492/ /pubmed/37111244 http://dx.doi.org/10.3390/ph16040487 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Assadpour, Elham Rezaei, Atefe Das, Sabya Sachi Krishna Rao, Balaga Venkata Singh, Sandeep Kumar Kharazmi, Mohammad Saeed Jha, Niraj Kumar Jha, Saurabh Kumar Prieto, Miguel A. Jafari, Seid Mahdi Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications |
title | Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications |
title_full | Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications |
title_fullStr | Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications |
title_full_unstemmed | Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications |
title_short | Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications |
title_sort | cannabidiol-loaded nanocarriers and their therapeutic applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141492/ https://www.ncbi.nlm.nih.gov/pubmed/37111244 http://dx.doi.org/10.3390/ph16040487 |
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