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Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies f...

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Autores principales: Assadpour, Elham, Rezaei, Atefe, Das, Sabya Sachi, Krishna Rao, Balaga Venkata, Singh, Sandeep Kumar, Kharazmi, Mohammad Saeed, Jha, Niraj Kumar, Jha, Saurabh Kumar, Prieto, Miguel A., Jafari, Seid Mahdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141492/
https://www.ncbi.nlm.nih.gov/pubmed/37111244
http://dx.doi.org/10.3390/ph16040487
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author Assadpour, Elham
Rezaei, Atefe
Das, Sabya Sachi
Krishna Rao, Balaga Venkata
Singh, Sandeep Kumar
Kharazmi, Mohammad Saeed
Jha, Niraj Kumar
Jha, Saurabh Kumar
Prieto, Miguel A.
Jafari, Seid Mahdi
author_facet Assadpour, Elham
Rezaei, Atefe
Das, Sabya Sachi
Krishna Rao, Balaga Venkata
Singh, Sandeep Kumar
Kharazmi, Mohammad Saeed
Jha, Niraj Kumar
Jha, Saurabh Kumar
Prieto, Miguel A.
Jafari, Seid Mahdi
author_sort Assadpour, Elham
collection PubMed
description Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.
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spelling pubmed-101414922023-04-29 Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications Assadpour, Elham Rezaei, Atefe Das, Sabya Sachi Krishna Rao, Balaga Venkata Singh, Sandeep Kumar Kharazmi, Mohammad Saeed Jha, Niraj Kumar Jha, Saurabh Kumar Prieto, Miguel A. Jafari, Seid Mahdi Pharmaceuticals (Basel) Review Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD. MDPI 2023-03-24 /pmc/articles/PMC10141492/ /pubmed/37111244 http://dx.doi.org/10.3390/ph16040487 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Assadpour, Elham
Rezaei, Atefe
Das, Sabya Sachi
Krishna Rao, Balaga Venkata
Singh, Sandeep Kumar
Kharazmi, Mohammad Saeed
Jha, Niraj Kumar
Jha, Saurabh Kumar
Prieto, Miguel A.
Jafari, Seid Mahdi
Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
title Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
title_full Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
title_fullStr Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
title_full_unstemmed Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
title_short Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications
title_sort cannabidiol-loaded nanocarriers and their therapeutic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141492/
https://www.ncbi.nlm.nih.gov/pubmed/37111244
http://dx.doi.org/10.3390/ph16040487
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