Mimicking Tumor Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-Fibroblast Model

BACKGROUND & AIMS: Patient-derived organoid cancer models are generated from epithelial tumor cells and reflect tumor characteristics. However, they lack the complexity of the tumor microenvironment, which is a key driver of tumorigenesis and therapy response. Here, we developed a colorectal can...

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Detalles Bibliográficos
Autores principales: Atanasova, Velina S., de Jesus Cardona, Crhistian, Hejret, Václav, Tiefenbacher, Andreas, Mair, Theresia, Tran, Loan, Pfneissl, Janette, Draganić, Kristina, Binder, Carina, Kabiljo, Julijan, Clement, Janik, Woeran, Katharina, Neudert, Barbara, Wohlhaupter, Sabrina, Haase, Astrid, Domazet, Sandra, Hengstschläger, Markus, Mitterhauser, Markus, Müllauer, Leonhard, Tichý, Boris, Bergmann, Michael, Schweikert, Gabriele, Hartl, Markus, Dolznig, Helmut, Egger, Gerda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141529/
https://www.ncbi.nlm.nih.gov/pubmed/36868311
http://dx.doi.org/10.1016/j.jcmgh.2023.02.014

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