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Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention
Extracellular vesicles (EVs) are implicated in several biological conditions, including bone metabolism disturbances in breast cancer patients (BCPs). These disorders hinder the adjustment of nutrition interventions due to changes in bone mineral density (BMD). The biophysical properties of EVs (e.g...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141602/ https://www.ncbi.nlm.nih.gov/pubmed/37111181 http://dx.doi.org/10.3390/nu15081963 |
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author | Coronado-Alvarado, Carlos D. Limon-Miro, Ana Teresa Mendivil-Alvarado, Herminia Lizardi-Mendoza, Jaime Carvajal-Millan, Elizabeth Méndez-Estrada, Rosa Olivia González-Ríos, Humberto Astiazaran-Garcia, Humberto |
author_facet | Coronado-Alvarado, Carlos D. Limon-Miro, Ana Teresa Mendivil-Alvarado, Herminia Lizardi-Mendoza, Jaime Carvajal-Millan, Elizabeth Méndez-Estrada, Rosa Olivia González-Ríos, Humberto Astiazaran-Garcia, Humberto |
author_sort | Coronado-Alvarado, Carlos D. |
collection | PubMed |
description | Extracellular vesicles (EVs) are implicated in several biological conditions, including bone metabolism disturbances in breast cancer patients (BCPs). These disorders hinder the adjustment of nutrition interventions due to changes in bone mineral density (BMD). The biophysical properties of EVs (e.g., size or electrostatic repulsion) affect their cellular uptake, however, their clinical relevance is unclear. In this study, we aimed to investigate the association between the biophysical properties of the plasma-derived EVs and BMDs in BCPs who received an individualized nutrition intervention during the first six months of antineoplastic treatment. As part of the nutritional assessment before and after the intervention, body composition including bone densitometry and plasma samples were obtained. In 16 BCPs, EVs were isolated using ExoQuick(®) and their biophysical properties were analyzed using light-scattering techniques. We found that the average hydrodynamic diameter of large EVs was associated with femoral neck bone mineral content, lumbar spine BMD, and neoplasms’ molecular subtypes. These results provide evidence that EVs play a role in BCPs’ bone disorders and suggest that the biophysical properties of EVs may serve as potential nutritional biomarkers. Further studies are needed to evaluate EVs’ biophysical properties as potential nutritional biomarkers in a clinical context. |
format | Online Article Text |
id | pubmed-10141602 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101416022023-04-29 Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention Coronado-Alvarado, Carlos D. Limon-Miro, Ana Teresa Mendivil-Alvarado, Herminia Lizardi-Mendoza, Jaime Carvajal-Millan, Elizabeth Méndez-Estrada, Rosa Olivia González-Ríos, Humberto Astiazaran-Garcia, Humberto Nutrients Article Extracellular vesicles (EVs) are implicated in several biological conditions, including bone metabolism disturbances in breast cancer patients (BCPs). These disorders hinder the adjustment of nutrition interventions due to changes in bone mineral density (BMD). The biophysical properties of EVs (e.g., size or electrostatic repulsion) affect their cellular uptake, however, their clinical relevance is unclear. In this study, we aimed to investigate the association between the biophysical properties of the plasma-derived EVs and BMDs in BCPs who received an individualized nutrition intervention during the first six months of antineoplastic treatment. As part of the nutritional assessment before and after the intervention, body composition including bone densitometry and plasma samples were obtained. In 16 BCPs, EVs were isolated using ExoQuick(®) and their biophysical properties were analyzed using light-scattering techniques. We found that the average hydrodynamic diameter of large EVs was associated with femoral neck bone mineral content, lumbar spine BMD, and neoplasms’ molecular subtypes. These results provide evidence that EVs play a role in BCPs’ bone disorders and suggest that the biophysical properties of EVs may serve as potential nutritional biomarkers. Further studies are needed to evaluate EVs’ biophysical properties as potential nutritional biomarkers in a clinical context. MDPI 2023-04-19 /pmc/articles/PMC10141602/ /pubmed/37111181 http://dx.doi.org/10.3390/nu15081963 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Coronado-Alvarado, Carlos D. Limon-Miro, Ana Teresa Mendivil-Alvarado, Herminia Lizardi-Mendoza, Jaime Carvajal-Millan, Elizabeth Méndez-Estrada, Rosa Olivia González-Ríos, Humberto Astiazaran-Garcia, Humberto Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention |
title | Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention |
title_full | Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention |
title_fullStr | Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention |
title_full_unstemmed | Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention |
title_short | Biophysical Parameters of Plasma-Derived Extracellular Vesicles as Potential Biomarkers of Bone Disturbances in Breast Cancer Patients Receiving an Individualized Nutrition Intervention |
title_sort | biophysical parameters of plasma-derived extracellular vesicles as potential biomarkers of bone disturbances in breast cancer patients receiving an individualized nutrition intervention |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141602/ https://www.ncbi.nlm.nih.gov/pubmed/37111181 http://dx.doi.org/10.3390/nu15081963 |
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