Cargando…

Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery

Uveal melanoma (UM) is a rare malignant cancer of the eye, with up to 50% of patients dying from metastasis, for which no effective treatment is available. Due to the rarity of the disease, there is a great need to harness the limited material available from primary tumors and metastases for advance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yin, Jie, Zhao, Gangyin, Kalirai, Helen, Coupland, Sarah E., Jochemsen, Aart G., Forn-Cuní, Gabriel, Wierenga, Annemijn P. A., Jager, Martine J., Snaar-Jagalska, B. Ewa, Groenewoud, Arwin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141637/ https://www.ncbi.nlm.nih.gov/pubmed/37111355 http://dx.doi.org/10.3390/ph16040598

Ejemplares similares

Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
por: Groenewoud, Arwin, et al.
Publicado: (2023)

XePhIR: the zebrafish xenograft phenotype interactive repository
por: Groenewoud, A, et al.
Publicado: (2022)

Novel Treatments of Uveal Melanoma Identified with a Synthetic Lethal CRISPR/Cas9 Screen
por: Glinkina, Kseniya, et al.
Publicado: (2022)

HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target
por: Souri, Zahra, et al.
Publicado: (2019)

Embryonic zebrafish xenograft assay of human cancer metastasis
por: Hill, David, et al.
Publicado: (2018)

TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models
por: Chen, Quanchi, et al.
Publicado: (2020)

Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target
por: Cao, Jinfeng, et al.
Publicado: (2018)

Expression of HDACs 1, 3 and 8 Is Upregulated in the Presence of Infiltrating Lymphocytes in Uveal Melanoma
por: Souri, Zahra, et al.
Publicado: (2021)

HDAC Inhibition Increases HLA Class I Expression in Uveal Melanoma
por: Souri, Zahra, et al.
Publicado: (2020)

Development of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model
por: Mercatali, Laura, et al.
Publicado: (2016)

Transforming growth factor-β signalling controls human breast cancer metastasis in a zebrafish xenograft model
por: Drabsch, Yvette, et al.
Publicado: (2013)

Preclinical Evaluation of Trabectedin in Combination With Targeted Inhibitors for Treatment of Metastatic Uveal Melanoma
por: Glinkina, Kseniya, et al.
Publicado: (2022)

Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma
por: Souri, Zahra, et al.
Publicado: (2019)

Iris Colour and the Risk of Developing Uveal Melanoma
por: Houtzagers, Laurien E., et al.
Publicado: (2020)

Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model
por: Tulotta, Claudia, et al.
Publicado: (2016)

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model
por: He, Shuning, et al.
Publicado: (2012)

Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model
por: van der Helm, Danny, et al.
Publicado: (2018)

Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model
por: Chen, Quanchi, et al.
Publicado: (2022)

Combined Mcl-1 and YAP1/TAZ inhibition for treatment of metastatic uveal melanoma
por: Glinkina, Kseniya A., et al.
Publicado: (2023)

Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model
por: Liverani, Chiara, et al.
Publicado: (2016)

Zebrafish in Inflammasome Research
por: Forn-Cuní, Gabriel, et al.
Publicado: (2019)

CORRECTION: Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model
por: Liverani, Chiara, et al.
Publicado: (2017)

Vascular Lakes in Uveal Melanoma and Their Association With Outcome
por: Jones, Hayley, et al.
Publicado: (2022)

MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators
por: Aughton, Karen, et al.
Publicado: (2020)

Ischemia Is Related to Tumour Genetics in Uveal Melanoma
por: Brouwer, Niels J., et al.
Publicado: (2019)

Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells
por: Chen, Lanpeng, et al.
Publicado: (2020)

Investigating the Role of DUSP4 in Uveal Melanoma
por: Aughton, Karen, et al.
Publicado: (2022)

LAG3 and Its Ligands Show Increased Expression in High-Risk Uveal Melanoma
por: Souri, Zahra, et al.
Publicado: (2021)

ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis
por: Krens, SF Gabby, et al.
Publicado: (2008)

Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution
por: Brouwer, Niels J., et al.
Publicado: (2019)

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?
por: van Weeghel, Christiaan, et al.
Publicado: (2019)

In Uveal Melanoma, Angiopoietin-2 but Not Angiopoietin-1 Is Increased in High-Risk Tumors, Providing a Potential Druggable Target
por: ten Voorde, Anna M.W., et al.
Publicado: (2021)

Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons
por: Hussain, Rumana N., et al.
Publicado: (2020)

Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture
por: Aughton, Karen, et al.
Publicado: (2020)

Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics
por: Wierenga, Annemijn P. A., et al.
Publicado: (2019)

MiRNAs Correlate with HLA Expression in Uveal Melanoma: Both Up- and Downregulation Are Related to Monosomy 3
por: Souri, Zahra, et al.
Publicado: (2021)

In-depth proteomic profiling of the uveal melanoma secretome
por: Angi, Martina, et al.
Publicado: (2016)

Lack of BAP1 protein expression in uveal melanoma is associated with increased metastatic risk and has utility in routine prognostic testing
por: Kalirai, H, et al.
Publicado: (2014)

Conserved gene regulation during acute inflammation between zebrafish and mammals
por: Forn-Cuní, G., et al.
Publicado: (2017)

So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020
por: Rodrigues, Manuel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qrj4ess44o1pi7hlslfufcmjnf