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Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury?

Nosocomial pneumonia is a leading cause of critical illness and mortality among seriously injured trauma patients. However, the link between injury and the development of nosocomial pneumonia is still not well recognized. Our work strongly suggests that mitochondrial damage-associated molecular patt...

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Autores principales: Macáková, Kristína, Kaczmarek, Elzbieta, Itagaki, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141656/
https://www.ncbi.nlm.nih.gov/pubmed/37108790
http://dx.doi.org/10.3390/ijms24087627
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author Macáková, Kristína
Kaczmarek, Elzbieta
Itagaki, Kiyoshi
author_facet Macáková, Kristína
Kaczmarek, Elzbieta
Itagaki, Kiyoshi
author_sort Macáková, Kristína
collection PubMed
description Nosocomial pneumonia is a leading cause of critical illness and mortality among seriously injured trauma patients. However, the link between injury and the development of nosocomial pneumonia is still not well recognized. Our work strongly suggests that mitochondrial damage-associated molecular patterns (mtDAMPs), especially mitochondrial formyl peptides (mtFPs) released by tissue injury, play a significant role in developing nosocomial pneumonia after a serious injury. Polymorphonuclear leukocytes (neutrophils, PMN) migrate toward the injury site by detecting mtFPs through formyl peptide receptor 1 (FPR1) to fight/contain bacterial infection and clean up debris. Activation of FPR1 by mtFPs enables PMN to reach the injury site; however, at the same time it leads to homo- and heterologous desensitization/internalization of chemokine receptors. Thus, PMN are not responsive to secondary infections, including those from bacteria-infected lungs. This may enable a progression of bacterial growth in the lungs and nosocomial pneumonia. We propose that the intratracheal application of exogenously isolated PMN may prevent pneumonia coupled with a serious injury.
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spelling pubmed-101416562023-04-29 Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury? Macáková, Kristína Kaczmarek, Elzbieta Itagaki, Kiyoshi Int J Mol Sci Perspective Nosocomial pneumonia is a leading cause of critical illness and mortality among seriously injured trauma patients. However, the link between injury and the development of nosocomial pneumonia is still not well recognized. Our work strongly suggests that mitochondrial damage-associated molecular patterns (mtDAMPs), especially mitochondrial formyl peptides (mtFPs) released by tissue injury, play a significant role in developing nosocomial pneumonia after a serious injury. Polymorphonuclear leukocytes (neutrophils, PMN) migrate toward the injury site by detecting mtFPs through formyl peptide receptor 1 (FPR1) to fight/contain bacterial infection and clean up debris. Activation of FPR1 by mtFPs enables PMN to reach the injury site; however, at the same time it leads to homo- and heterologous desensitization/internalization of chemokine receptors. Thus, PMN are not responsive to secondary infections, including those from bacteria-infected lungs. This may enable a progression of bacterial growth in the lungs and nosocomial pneumonia. We propose that the intratracheal application of exogenously isolated PMN may prevent pneumonia coupled with a serious injury. MDPI 2023-04-21 /pmc/articles/PMC10141656/ /pubmed/37108790 http://dx.doi.org/10.3390/ijms24087627 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Macáková, Kristína
Kaczmarek, Elzbieta
Itagaki, Kiyoshi
Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury?
title Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury?
title_full Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury?
title_fullStr Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury?
title_full_unstemmed Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury?
title_short Can Neutrophils Prevent Nosocomial Pneumonia after Serious Injury?
title_sort can neutrophils prevent nosocomial pneumonia after serious injury?
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141656/
https://www.ncbi.nlm.nih.gov/pubmed/37108790
http://dx.doi.org/10.3390/ijms24087627
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