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The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature

Primary neuroendocrine tumors (NETs) of the breast are considered a rare and undervalued subtype of breast carcinoma that occur mainly in postmenopausal women and are graded as G1 or G2 NETs or an invasive neuroendocrine carcinoma (NEC) (small cell or large cell). To establish a final diagnosis of b...

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Autores principales: Chiorean, Diana Maria, Mitranovici, Melinda-Ildiko, Mureșan, Maria Cezara, Buicu, Corneliu-Florin, Moraru, Raluca, Moraru, Liviu, Cotoi, Titiana Cornelia, Cotoi, Ovidiu Simion, Apostol, Adrian, Turdean, Sabin Gligore, Mărginean, Claudiu, Petre, Ion, Oală, Ioan Emilian, Simon-Szabo, Zsuzsanna, Ivan, Viviana, Roșca, Ancuța Noela, Toru, Havva Serap
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141693/
https://www.ncbi.nlm.nih.gov/pubmed/37109630
http://dx.doi.org/10.3390/medicina59040672
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author Chiorean, Diana Maria
Mitranovici, Melinda-Ildiko
Mureșan, Maria Cezara
Buicu, Corneliu-Florin
Moraru, Raluca
Moraru, Liviu
Cotoi, Titiana Cornelia
Cotoi, Ovidiu Simion
Apostol, Adrian
Turdean, Sabin Gligore
Mărginean, Claudiu
Petre, Ion
Oală, Ioan Emilian
Simon-Szabo, Zsuzsanna
Ivan, Viviana
Roșca, Ancuța Noela
Toru, Havva Serap
author_facet Chiorean, Diana Maria
Mitranovici, Melinda-Ildiko
Mureșan, Maria Cezara
Buicu, Corneliu-Florin
Moraru, Raluca
Moraru, Liviu
Cotoi, Titiana Cornelia
Cotoi, Ovidiu Simion
Apostol, Adrian
Turdean, Sabin Gligore
Mărginean, Claudiu
Petre, Ion
Oală, Ioan Emilian
Simon-Szabo, Zsuzsanna
Ivan, Viviana
Roșca, Ancuța Noela
Toru, Havva Serap
author_sort Chiorean, Diana Maria
collection PubMed
description Primary neuroendocrine tumors (NETs) of the breast are considered a rare and undervalued subtype of breast carcinoma that occur mainly in postmenopausal women and are graded as G1 or G2 NETs or an invasive neuroendocrine carcinoma (NEC) (small cell or large cell). To establish a final diagnosis of breast carcinoma with neuroendocrine differentiation, it is essential to perform an immunohistochemical profile of the tumor, using antibodies against synaptophysin or chromogranin, as well as the MIB-1 proliferation index, one of the most controversial markers in breast pathology regarding its methodology in current clinical practice. A standardization error between institutions and pathologists regarding the evaluation of the MIB-1 proliferation index is present. Another challenge refers to the counting process of MIB-1′s expressiveness, which is known as a time-consuming process. The involvement of AI (artificial intelligence) automated systems could be a solution for diagnosing early stages, as well. We present the case of a post-menopausal 79-year-old woman diagnosed with primary neuroendocrine carcinoma of the breast (NECB). The purpose of this paper is to expose the interpretation of MIB-1 expression in our patient’ s case of breast neuroendocrine carcinoma, assisted by artificial intelligence (AI) software (HALO—IndicaLabs), and to analyze the associations between MIB-1 and common histopathological parameters.
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spelling pubmed-101416932023-04-29 The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature Chiorean, Diana Maria Mitranovici, Melinda-Ildiko Mureșan, Maria Cezara Buicu, Corneliu-Florin Moraru, Raluca Moraru, Liviu Cotoi, Titiana Cornelia Cotoi, Ovidiu Simion Apostol, Adrian Turdean, Sabin Gligore Mărginean, Claudiu Petre, Ion Oală, Ioan Emilian Simon-Szabo, Zsuzsanna Ivan, Viviana Roșca, Ancuța Noela Toru, Havva Serap Medicina (Kaunas) Case Report Primary neuroendocrine tumors (NETs) of the breast are considered a rare and undervalued subtype of breast carcinoma that occur mainly in postmenopausal women and are graded as G1 or G2 NETs or an invasive neuroendocrine carcinoma (NEC) (small cell or large cell). To establish a final diagnosis of breast carcinoma with neuroendocrine differentiation, it is essential to perform an immunohistochemical profile of the tumor, using antibodies against synaptophysin or chromogranin, as well as the MIB-1 proliferation index, one of the most controversial markers in breast pathology regarding its methodology in current clinical practice. A standardization error between institutions and pathologists regarding the evaluation of the MIB-1 proliferation index is present. Another challenge refers to the counting process of MIB-1′s expressiveness, which is known as a time-consuming process. The involvement of AI (artificial intelligence) automated systems could be a solution for diagnosing early stages, as well. We present the case of a post-menopausal 79-year-old woman diagnosed with primary neuroendocrine carcinoma of the breast (NECB). The purpose of this paper is to expose the interpretation of MIB-1 expression in our patient’ s case of breast neuroendocrine carcinoma, assisted by artificial intelligence (AI) software (HALO—IndicaLabs), and to analyze the associations between MIB-1 and common histopathological parameters. MDPI 2023-03-28 /pmc/articles/PMC10141693/ /pubmed/37109630 http://dx.doi.org/10.3390/medicina59040672 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Chiorean, Diana Maria
Mitranovici, Melinda-Ildiko
Mureșan, Maria Cezara
Buicu, Corneliu-Florin
Moraru, Raluca
Moraru, Liviu
Cotoi, Titiana Cornelia
Cotoi, Ovidiu Simion
Apostol, Adrian
Turdean, Sabin Gligore
Mărginean, Claudiu
Petre, Ion
Oală, Ioan Emilian
Simon-Szabo, Zsuzsanna
Ivan, Viviana
Roșca, Ancuța Noela
Toru, Havva Serap
The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature
title The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature
title_full The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature
title_fullStr The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature
title_full_unstemmed The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature
title_short The Approach of Artificial Intelligence in Neuroendocrine Carcinomas of the Breast: A Next Step towards Precision Pathology?—A Case Report and Review of the Literature
title_sort approach of artificial intelligence in neuroendocrine carcinomas of the breast: a next step towards precision pathology?—a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141693/
https://www.ncbi.nlm.nih.gov/pubmed/37109630
http://dx.doi.org/10.3390/medicina59040672
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