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Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine

In myocardial infarction, a blockage in one of the coronary arteries leads to ischemic conditions in the left ventricle of the myocardium and, therefore, to significant death of contractile cardiac cells. This process leads to the formation of scar tissue, which reduces heart functionality. Cardiac...

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Autores principales: Shilo, Malka, Baruch, Ester-Sapir, Wertheim, Lior, Oved, Hadas, Shapira, Assaf, Dvir, Tal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141701/
https://www.ncbi.nlm.nih.gov/pubmed/37111783
http://dx.doi.org/10.3390/pharmaceutics15041298
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author Shilo, Malka
Baruch, Ester-Sapir
Wertheim, Lior
Oved, Hadas
Shapira, Assaf
Dvir, Tal
author_facet Shilo, Malka
Baruch, Ester-Sapir
Wertheim, Lior
Oved, Hadas
Shapira, Assaf
Dvir, Tal
author_sort Shilo, Malka
collection PubMed
description In myocardial infarction, a blockage in one of the coronary arteries leads to ischemic conditions in the left ventricle of the myocardium and, therefore, to significant death of contractile cardiac cells. This process leads to the formation of scar tissue, which reduces heart functionality. Cardiac tissue engineering is an interdisciplinary technology that treats the injured myocardium and improves its functionality. However, in many cases, mainly when employing injectable hydrogels, the treatment may be partial because it does not fully cover the diseased area and, therefore, may not be effective and even cause conduction disorders. Here, we report a hybrid nanocomposite material composed of gold nanoparticles and an extracellular matrix-based hydrogel. Such a hybrid hydrogel could support cardiac cell growth and promote cardiac tissue assembly. After injection of the hybrid material into the diseased area of the heart, it could be efficiently imaged by magnetic resonance imaging (MRI). Furthermore, as the scar tissue could also be detected by MRI, a distinction between the diseased area and the treatment could be made, providing information about the ability of the hydrogel to cover the scar. We envision that such a nanocomposite hydrogel may improve the accuracy of tissue engineering treatment.
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spelling pubmed-101417012023-04-29 Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine Shilo, Malka Baruch, Ester-Sapir Wertheim, Lior Oved, Hadas Shapira, Assaf Dvir, Tal Pharmaceutics Article In myocardial infarction, a blockage in one of the coronary arteries leads to ischemic conditions in the left ventricle of the myocardium and, therefore, to significant death of contractile cardiac cells. This process leads to the formation of scar tissue, which reduces heart functionality. Cardiac tissue engineering is an interdisciplinary technology that treats the injured myocardium and improves its functionality. However, in many cases, mainly when employing injectable hydrogels, the treatment may be partial because it does not fully cover the diseased area and, therefore, may not be effective and even cause conduction disorders. Here, we report a hybrid nanocomposite material composed of gold nanoparticles and an extracellular matrix-based hydrogel. Such a hybrid hydrogel could support cardiac cell growth and promote cardiac tissue assembly. After injection of the hybrid material into the diseased area of the heart, it could be efficiently imaged by magnetic resonance imaging (MRI). Furthermore, as the scar tissue could also be detected by MRI, a distinction between the diseased area and the treatment could be made, providing information about the ability of the hydrogel to cover the scar. We envision that such a nanocomposite hydrogel may improve the accuracy of tissue engineering treatment. MDPI 2023-04-20 /pmc/articles/PMC10141701/ /pubmed/37111783 http://dx.doi.org/10.3390/pharmaceutics15041298 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shilo, Malka
Baruch, Ester-Sapir
Wertheim, Lior
Oved, Hadas
Shapira, Assaf
Dvir, Tal
Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine
title Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine
title_full Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine
title_fullStr Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine
title_full_unstemmed Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine
title_short Imageable AuNP-ECM Hydrogel Tissue Implants for Regenerative Medicine
title_sort imageable aunp-ecm hydrogel tissue implants for regenerative medicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141701/
https://www.ncbi.nlm.nih.gov/pubmed/37111783
http://dx.doi.org/10.3390/pharmaceutics15041298
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