Simvastatin Reduces Doxorubicin-Induced Cardiotoxicity: Effects beyond Its Antioxidant Activity

This study aimed to evaluate if Simvastatin can reduce, and/or prevent, Doxorubicin (Doxo)-induced cardiotoxicity. H9c2 cells were treated with Simvastatin (10 µM) for 4 h and then Doxo (1 µM) was added, and the effects on oxidative stress, calcium homeostasis, and apoptosis were evaluated after 20...

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Detalles Bibliográficos
Autores principales: Pecoraro, Michela, Marzocco, Stefania, Belvedere, Raffaella, Petrella, Antonello, Franceschelli, Silvia, Popolo, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141713/
https://www.ncbi.nlm.nih.gov/pubmed/37108737
http://dx.doi.org/10.3390/ijms24087573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141713/
https://www.ncbi.nlm.nih.gov/pubmed/37108737
http://dx.doi.org/10.3390/ijms24087573

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