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What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review

Irritable bowel syndrome is a prototypical disorder of the brain–gut–microbiome axis, although the underlying pathogenesis and mechanisms remain incompletely understood. With the recent advances in ‘omics’ technologies, studies have attempted to uncover IBS-specific variations in the host–microbiome...

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Autores principales: Ng, Qin Xiang, Yau, Chun En, Yaow, Clyve Yu Leon, Chong, Ryan Ian Houe, Chong, Nicolette Zy-Yin, Teoh, Seth En, Lim, Yu Liang, Soh, Alex Yu Sen, Ng, Wee Khoon, Thumboo, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142038/
https://www.ncbi.nlm.nih.gov/pubmed/37110143
http://dx.doi.org/10.3390/metabo13040484
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author Ng, Qin Xiang
Yau, Chun En
Yaow, Clyve Yu Leon
Chong, Ryan Ian Houe
Chong, Nicolette Zy-Yin
Teoh, Seth En
Lim, Yu Liang
Soh, Alex Yu Sen
Ng, Wee Khoon
Thumboo, Julian
author_facet Ng, Qin Xiang
Yau, Chun En
Yaow, Clyve Yu Leon
Chong, Ryan Ian Houe
Chong, Nicolette Zy-Yin
Teoh, Seth En
Lim, Yu Liang
Soh, Alex Yu Sen
Ng, Wee Khoon
Thumboo, Julian
author_sort Ng, Qin Xiang
collection PubMed
description Irritable bowel syndrome is a prototypical disorder of the brain–gut–microbiome axis, although the underlying pathogenesis and mechanisms remain incompletely understood. With the recent advances in ‘omics’ technologies, studies have attempted to uncover IBS-specific variations in the host–microbiome profile and function. However, no biomarker has been identified to date. Given the high inter-individual and day-to-day variability of the gut microbiota, and a lack of agreement across the large number of microbiome studies, this review focused on omics studies that had sampling at more than one time point. A systematic literature search was performed using various combinations of the search terms “Irritable Bowel Syndrome” and “Omics” in the Medline, EMBASE, and Cochrane Library up to 1 December 2022. A total of 16 original studies were reviewed. These multi-omics studies have implicated Bacteroides, Faecalibacterium prausnitzii, Ruminococcus spp., and Bifidobacteria in IBS and treatment response, found altered metabolite profiles in serum, faecal, or urinary samples taken from IBS patients compared to the healthy controls, and revealed enrichment in the immune and inflammation-related pathways. They also demonstrated the possible therapeutic mechanisms of diet interventions, for example, synbiotics and low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diets on microbial metabolites. However, there was significant heterogeneity among the studies and no uniform characteristics of IBS-related gut microbiota. There is a need to further study these putative mechanisms and also ensure that they can be translated to therapeutic benefits for patients with IBS.
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spelling pubmed-101420382023-04-29 What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review Ng, Qin Xiang Yau, Chun En Yaow, Clyve Yu Leon Chong, Ryan Ian Houe Chong, Nicolette Zy-Yin Teoh, Seth En Lim, Yu Liang Soh, Alex Yu Sen Ng, Wee Khoon Thumboo, Julian Metabolites Systematic Review Irritable bowel syndrome is a prototypical disorder of the brain–gut–microbiome axis, although the underlying pathogenesis and mechanisms remain incompletely understood. With the recent advances in ‘omics’ technologies, studies have attempted to uncover IBS-specific variations in the host–microbiome profile and function. However, no biomarker has been identified to date. Given the high inter-individual and day-to-day variability of the gut microbiota, and a lack of agreement across the large number of microbiome studies, this review focused on omics studies that had sampling at more than one time point. A systematic literature search was performed using various combinations of the search terms “Irritable Bowel Syndrome” and “Omics” in the Medline, EMBASE, and Cochrane Library up to 1 December 2022. A total of 16 original studies were reviewed. These multi-omics studies have implicated Bacteroides, Faecalibacterium prausnitzii, Ruminococcus spp., and Bifidobacteria in IBS and treatment response, found altered metabolite profiles in serum, faecal, or urinary samples taken from IBS patients compared to the healthy controls, and revealed enrichment in the immune and inflammation-related pathways. They also demonstrated the possible therapeutic mechanisms of diet interventions, for example, synbiotics and low fermentable oligosaccharides, disaccharides, monosaccharides, and polyol (FODMAP) diets on microbial metabolites. However, there was significant heterogeneity among the studies and no uniform characteristics of IBS-related gut microbiota. There is a need to further study these putative mechanisms and also ensure that they can be translated to therapeutic benefits for patients with IBS. MDPI 2023-03-28 /pmc/articles/PMC10142038/ /pubmed/37110143 http://dx.doi.org/10.3390/metabo13040484 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Ng, Qin Xiang
Yau, Chun En
Yaow, Clyve Yu Leon
Chong, Ryan Ian Houe
Chong, Nicolette Zy-Yin
Teoh, Seth En
Lim, Yu Liang
Soh, Alex Yu Sen
Ng, Wee Khoon
Thumboo, Julian
What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review
title What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review
title_full What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review
title_fullStr What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review
title_full_unstemmed What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review
title_short What Has Longitudinal ‘Omics’ Studies Taught Us about Irritable Bowel Syndrome? A Systematic Review
title_sort what has longitudinal ‘omics’ studies taught us about irritable bowel syndrome? a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142038/
https://www.ncbi.nlm.nih.gov/pubmed/37110143
http://dx.doi.org/10.3390/metabo13040484
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