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The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva

Purpose: To evaluate the usefulness of CT temporal subtraction (TS) images for detecting emerging or growing ectopic bone lesions in fibrodysplasia ossificans progressiva (FOP). Materials and Methods: Four patients with FOP were retrospectively included in this study. TS images were produced by subt...

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Autores principales: Iima, Mami, Sakamoto, Ryo, Kakigi, Takahide, Yamamoto, Akira, Otsuki, Bungo, Nakamoto, Yuji, Toguchida, Junya, Matsuda, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142082/
https://www.ncbi.nlm.nih.gov/pubmed/37104133
http://dx.doi.org/10.3390/tomography9020062
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author Iima, Mami
Sakamoto, Ryo
Kakigi, Takahide
Yamamoto, Akira
Otsuki, Bungo
Nakamoto, Yuji
Toguchida, Junya
Matsuda, Shuichi
author_facet Iima, Mami
Sakamoto, Ryo
Kakigi, Takahide
Yamamoto, Akira
Otsuki, Bungo
Nakamoto, Yuji
Toguchida, Junya
Matsuda, Shuichi
author_sort Iima, Mami
collection PubMed
description Purpose: To evaluate the usefulness of CT temporal subtraction (TS) images for detecting emerging or growing ectopic bone lesions in fibrodysplasia ossificans progressiva (FOP). Materials and Methods: Four patients with FOP were retrospectively included in this study. TS images were produced by subtracting previously registered CT images from the current images. Two residents and two board-certified radiologists independently interpreted a pair of current and previous CT images for each subject with or without TS images. Changes in the visibility of the lesion, the usefulness of TS images for lesions with TS images, and the interpreter’s confidence level in their interpretation of each scan were assessed on a semiquantitative 5-point scale (0–4). The Wilcoxon signed-rank test was used to compare the evaluated scores between datasets with and without TS images. Results: The number of growing lesions tended to be larger than that of the emerging lesions in all cases. A higher sensitivity was found in residents and radiologists using TS compared to those not using TS. For all residents and radiologists, the dataset with TS tended to have more false-positive scans than the dataset without TS. All the interpreters recognized TS as useful, and confidence levels when using TS tended to be lower or the same as when not using TS for two residents and one radiologist. Conclusions: TS improved the sensitivity of all interpreters in detecting emerging or growing ectopic bone lesions in patients with FOP. TS could be applied further, including the areas of systematic bone disease.
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spelling pubmed-101420822023-04-29 The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva Iima, Mami Sakamoto, Ryo Kakigi, Takahide Yamamoto, Akira Otsuki, Bungo Nakamoto, Yuji Toguchida, Junya Matsuda, Shuichi Tomography Article Purpose: To evaluate the usefulness of CT temporal subtraction (TS) images for detecting emerging or growing ectopic bone lesions in fibrodysplasia ossificans progressiva (FOP). Materials and Methods: Four patients with FOP were retrospectively included in this study. TS images were produced by subtracting previously registered CT images from the current images. Two residents and two board-certified radiologists independently interpreted a pair of current and previous CT images for each subject with or without TS images. Changes in the visibility of the lesion, the usefulness of TS images for lesions with TS images, and the interpreter’s confidence level in their interpretation of each scan were assessed on a semiquantitative 5-point scale (0–4). The Wilcoxon signed-rank test was used to compare the evaluated scores between datasets with and without TS images. Results: The number of growing lesions tended to be larger than that of the emerging lesions in all cases. A higher sensitivity was found in residents and radiologists using TS compared to those not using TS. For all residents and radiologists, the dataset with TS tended to have more false-positive scans than the dataset without TS. All the interpreters recognized TS as useful, and confidence levels when using TS tended to be lower or the same as when not using TS for two residents and one radiologist. Conclusions: TS improved the sensitivity of all interpreters in detecting emerging or growing ectopic bone lesions in patients with FOP. TS could be applied further, including the areas of systematic bone disease. MDPI 2023-04-03 /pmc/articles/PMC10142082/ /pubmed/37104133 http://dx.doi.org/10.3390/tomography9020062 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iima, Mami
Sakamoto, Ryo
Kakigi, Takahide
Yamamoto, Akira
Otsuki, Bungo
Nakamoto, Yuji
Toguchida, Junya
Matsuda, Shuichi
The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva
title The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva
title_full The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva
title_fullStr The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva
title_full_unstemmed The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva
title_short The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva
title_sort efficacy of ct temporal subtraction images for fibrodysplasia ossificans progressiva
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142082/
https://www.ncbi.nlm.nih.gov/pubmed/37104133
http://dx.doi.org/10.3390/tomography9020062
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