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Taq-Polymerase Stop Assay to Determine Target Selectivity of G4 Ligands in Native Promoter Sequences of MYC, TERT, and KIT Oncogenes

Computational and high-throughput experimental methods predict thousands of potential quadruplex sequences (PQSs) in the human genome. Often these PQSs contain more than four G-runs, which introduce additional uncertainty into the conformational polymorphism of the G4 DNA. G4-specific ligands, which...

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Detalles Bibliográficos
Autores principales:	Chashchina, Galina V., Tevonyan, Liana L., Beniaminov, Artemy D., Kaluzhny, Dmitry N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142109/ https://www.ncbi.nlm.nih.gov/pubmed/37111301 http://dx.doi.org/10.3390/ph16040544

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