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Paediatric Asthma and the Microbiome: A Systematic Review

Evidence from the literature suggests an association between the microbiome and asthma development. Here, we aimed to identify the current evidence for the association between asthma and the upper airway, lower airway and/or the gut microbiome. An electronic systemic search of PubMed, EBSCO, Science...

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Autores principales: Aldriwesh, Marwh G., Al-Mutairi, Abrar M., Alharbi, Azzah S., Aljohani, Hassan Y., Alzahrani, Nabeel A., Ajina, Reham, Alanazi, Abdullah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142236/
https://www.ncbi.nlm.nih.gov/pubmed/37110362
http://dx.doi.org/10.3390/microorganisms11040939
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author Aldriwesh, Marwh G.
Al-Mutairi, Abrar M.
Alharbi, Azzah S.
Aljohani, Hassan Y.
Alzahrani, Nabeel A.
Ajina, Reham
Alanazi, Abdullah M.
author_facet Aldriwesh, Marwh G.
Al-Mutairi, Abrar M.
Alharbi, Azzah S.
Aljohani, Hassan Y.
Alzahrani, Nabeel A.
Ajina, Reham
Alanazi, Abdullah M.
author_sort Aldriwesh, Marwh G.
collection PubMed
description Evidence from the literature suggests an association between the microbiome and asthma development. Here, we aimed to identify the current evidence for the association between asthma and the upper airway, lower airway and/or the gut microbiome. An electronic systemic search of PubMed, EBSCO, Science Direct and Web of Science was conducted until February 2022 to identify the eligible studies. The Newcastle–Ottawa Scale and the Systematic Review Centre for Laboratory Animal Experimentation risk of the bias tools were used to assess quality of included studies. Twenty-five studies met the inclusion criteria. Proteobacteria and Firmicutes were identified as being significantly higher in the asthmatic children compared with the healthy controls. The high relative abundance of Veillonella, Prevotella and Haemophilus in the microbiome of the upper airway in early infancy was associated with a higher risk of asthma development later in life. The gut microbiome analyses indicated that a high relative abundance of Clostridium in early childhood might be associated with asthma development later in life. The findings reported here serve as potential microbiome signatures associated with the increased risk of asthma development. There is a need for large longitudinal studies to further identify high-risk infants, which will help in design strategies and prevention mechanisms to avoid asthma early in life.
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spelling pubmed-101422362023-04-29 Paediatric Asthma and the Microbiome: A Systematic Review Aldriwesh, Marwh G. Al-Mutairi, Abrar M. Alharbi, Azzah S. Aljohani, Hassan Y. Alzahrani, Nabeel A. Ajina, Reham Alanazi, Abdullah M. Microorganisms Review Evidence from the literature suggests an association between the microbiome and asthma development. Here, we aimed to identify the current evidence for the association between asthma and the upper airway, lower airway and/or the gut microbiome. An electronic systemic search of PubMed, EBSCO, Science Direct and Web of Science was conducted until February 2022 to identify the eligible studies. The Newcastle–Ottawa Scale and the Systematic Review Centre for Laboratory Animal Experimentation risk of the bias tools were used to assess quality of included studies. Twenty-five studies met the inclusion criteria. Proteobacteria and Firmicutes were identified as being significantly higher in the asthmatic children compared with the healthy controls. The high relative abundance of Veillonella, Prevotella and Haemophilus in the microbiome of the upper airway in early infancy was associated with a higher risk of asthma development later in life. The gut microbiome analyses indicated that a high relative abundance of Clostridium in early childhood might be associated with asthma development later in life. The findings reported here serve as potential microbiome signatures associated with the increased risk of asthma development. There is a need for large longitudinal studies to further identify high-risk infants, which will help in design strategies and prevention mechanisms to avoid asthma early in life. MDPI 2023-04-03 /pmc/articles/PMC10142236/ /pubmed/37110362 http://dx.doi.org/10.3390/microorganisms11040939 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aldriwesh, Marwh G.
Al-Mutairi, Abrar M.
Alharbi, Azzah S.
Aljohani, Hassan Y.
Alzahrani, Nabeel A.
Ajina, Reham
Alanazi, Abdullah M.
Paediatric Asthma and the Microbiome: A Systematic Review
title Paediatric Asthma and the Microbiome: A Systematic Review
title_full Paediatric Asthma and the Microbiome: A Systematic Review
title_fullStr Paediatric Asthma and the Microbiome: A Systematic Review
title_full_unstemmed Paediatric Asthma and the Microbiome: A Systematic Review
title_short Paediatric Asthma and the Microbiome: A Systematic Review
title_sort paediatric asthma and the microbiome: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142236/
https://www.ncbi.nlm.nih.gov/pubmed/37110362
http://dx.doi.org/10.3390/microorganisms11040939
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