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Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature

Fungemia is a fatal systemic infection that can occur in immunocompromised patients. Despite that, antifungal stewardship is spreading widely, but the mortality rate is extremely high, showing 40–60%. Loderomyces elongiporus is a newly morphologically detected pathogen, first described in 1994, foll...

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Autores principales: Asai, Nobuhiro, Shibata, Yuichi, Nakamura, Akiko, Suematsu, Hiroyuki, Yamada, Atsuko, Ohno, Tomoko, Sakanashi, Daisuke, Kawamoto, Yuzuka, Miyazaki, Narimi, Koita, Isao, Kato, Hideo, Hagihara, Mao, Ohta, Hirotoshi, Mikamo, Hiroshige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142367/
https://www.ncbi.nlm.nih.gov/pubmed/37110499
http://dx.doi.org/10.3390/microorganisms11041076
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author Asai, Nobuhiro
Shibata, Yuichi
Nakamura, Akiko
Suematsu, Hiroyuki
Yamada, Atsuko
Ohno, Tomoko
Sakanashi, Daisuke
Kawamoto, Yuzuka
Miyazaki, Narimi
Koita, Isao
Kato, Hideo
Hagihara, Mao
Ohta, Hirotoshi
Mikamo, Hiroshige
author_facet Asai, Nobuhiro
Shibata, Yuichi
Nakamura, Akiko
Suematsu, Hiroyuki
Yamada, Atsuko
Ohno, Tomoko
Sakanashi, Daisuke
Kawamoto, Yuzuka
Miyazaki, Narimi
Koita, Isao
Kato, Hideo
Hagihara, Mao
Ohta, Hirotoshi
Mikamo, Hiroshige
author_sort Asai, Nobuhiro
collection PubMed
description Fungemia is a fatal systemic infection that can occur in immunocompromised patients. Despite that, antifungal stewardship is spreading widely, but the mortality rate is extremely high, showing 40–60%. Loderomyces elongiporus is a newly morphologically detected pathogen, first described in 1994, followed by isolation in humans in 2008. It has been misrecognized as Candida parapsilosis. Recently, fever attributable to L. elongisporus fungemia cases has been reported, and the etiology and clinical features are still unknown. Here, we present three successfully treated L. elongisporus fungemia cases by echinocandin. In total, 11 cases were reviewed, including ours. Six of the eleven cases (55%) had external devices. All cases had some immunocompromised conditions or underlying diseases, such as diabetes mellitus, lung cancer, etc. Six patients survived, and the remaining five died. Seven patients who had received echinocandin initially survived. Risk factors for L. elongiporus fungemia overlap with those of candidemia. Even though there is no breakpoint for L. elongiporus, echinocandin can be a helpful treatment regimen for L. elongiporus fungemia.
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spelling pubmed-101423672023-04-29 Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature Asai, Nobuhiro Shibata, Yuichi Nakamura, Akiko Suematsu, Hiroyuki Yamada, Atsuko Ohno, Tomoko Sakanashi, Daisuke Kawamoto, Yuzuka Miyazaki, Narimi Koita, Isao Kato, Hideo Hagihara, Mao Ohta, Hirotoshi Mikamo, Hiroshige Microorganisms Communication Fungemia is a fatal systemic infection that can occur in immunocompromised patients. Despite that, antifungal stewardship is spreading widely, but the mortality rate is extremely high, showing 40–60%. Loderomyces elongiporus is a newly morphologically detected pathogen, first described in 1994, followed by isolation in humans in 2008. It has been misrecognized as Candida parapsilosis. Recently, fever attributable to L. elongisporus fungemia cases has been reported, and the etiology and clinical features are still unknown. Here, we present three successfully treated L. elongisporus fungemia cases by echinocandin. In total, 11 cases were reviewed, including ours. Six of the eleven cases (55%) had external devices. All cases had some immunocompromised conditions or underlying diseases, such as diabetes mellitus, lung cancer, etc. Six patients survived, and the remaining five died. Seven patients who had received echinocandin initially survived. Risk factors for L. elongiporus fungemia overlap with those of candidemia. Even though there is no breakpoint for L. elongiporus, echinocandin can be a helpful treatment regimen for L. elongiporus fungemia. MDPI 2023-04-20 /pmc/articles/PMC10142367/ /pubmed/37110499 http://dx.doi.org/10.3390/microorganisms11041076 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Asai, Nobuhiro
Shibata, Yuichi
Nakamura, Akiko
Suematsu, Hiroyuki
Yamada, Atsuko
Ohno, Tomoko
Sakanashi, Daisuke
Kawamoto, Yuzuka
Miyazaki, Narimi
Koita, Isao
Kato, Hideo
Hagihara, Mao
Ohta, Hirotoshi
Mikamo, Hiroshige
Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature
title Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature
title_full Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature
title_fullStr Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature
title_full_unstemmed Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature
title_short Three Successfully Treated Cases of Lodderomyces elongisporus Fungemia: Case Reports and a Review of the Literature
title_sort three successfully treated cases of lodderomyces elongisporus fungemia: case reports and a review of the literature
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142367/
https://www.ncbi.nlm.nih.gov/pubmed/37110499
http://dx.doi.org/10.3390/microorganisms11041076
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