Cargando…

Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics

Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely associated with diseases such as atherosclerosis and hypertension, and metabolic disorders such as diabetes and hyperlipide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shanmugham, Meyammai, Bellanger, Sophie, Leo, Chen Huei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142468/ https://www.ncbi.nlm.nih.gov/pubmed/37111261 http://dx.doi.org/10.3390/ph16040504

Ejemplares similares

Time-dependent specific molecular signatures of inflammation and remodelling are associated with trimethylamine-N-oxide (TMAO)-induced endothelial cell dysfunction
por: Shanmugham, Meyammai, et al.
Publicado: (2023)

Trimethylamine N-oxide (TMAO) in human health
por: Gatarek, Paulina, et al.
Publicado: (2021)

Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
por: Chen, Ming-liang, et al.
Publicado: (2016)

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target
por: Janeiro, Manuel H., et al.
Publicado: (2018)

Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor
por: Lakshmi, G. B. V. S., et al.
Publicado: (2021)

Trimethylamine-N-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism
por: Ding, Lin, et al.
Publicado: (2018)

Association of Urinary and Plasma Levels of Trimethylamine N-Oxide (TMAO) with Foods
por: Lombardo, Mauro, et al.
Publicado: (2021)

Association of the Chronotype Score with Circulating Trimethylamine N-Oxide (TMAO) Concentrations
por: Barrea, Luigi, et al.
Publicado: (2021)

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases
por: Constantino-Jonapa, Luis A., et al.
Publicado: (2023)

Simultaneous Measurement of Urinary Trimethylamine (TMA) and Trimethylamine N-Oxide (TMAO) by Liquid Chromatography–Mass Spectrometry
por: Jia, Xun, et al.
Publicado: (2020)

Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome
por: Barrea, Luigi, et al.
Publicado: (2018)

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
por: Randrianarisoa, Elko, et al.
Publicado: (2016)

Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease
por: Roncal, Carmen, et al.
Publicado: (2019)

Connections between serum Trimethylamine N-Oxide (TMAO), a gut-derived metabolite, and vascular biomarkers evaluating arterial stiffness and subclinical atherosclerosis in children with obesity
por: Mihuta, Monica Simina, et al.
Publicado: (2023)

Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients
por: Hai, Xin, et al.
Publicado: (2015)

Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO)
por: Mitchell, Sarah M., et al.
Publicado: (2019)

2297 The direct effect of trimethylamine N-oxide (TMAO) on cardiac muscle contractile mechanics
por: Oakley, Carlee I., et al.
Publicado: (2018)

Neighborhood Environment Associates with Trimethylamine-N-Oxide (TMAO) as a Cardiovascular Risk Marker
por: Farmer, Nicole, et al.
Publicado: (2021)

Trimethylamine N-oxide (TMAO) Is not Associated with Cardiometabolic Phenotypes and Inflammatory Markers in Children and Adults
por: Andraos, Stephanie, et al.
Publicado: (2020)

Association of Trimethylamine N-Oxide (TMAO) with the Clinical Severity of Hidradenitis Suppurativa (Acne Inversa)
por: Barrea, Luigi, et al.
Publicado: (2021)

Trimethylamine N-Oxide (TMAO) and Indoxyl Sulfate Concentrations in Patients with Alcohol Use Disorder
por: Coulbault, Laurent, et al.
Publicado: (2022)

Trimethylamine N-oxide (TMAO) in patients with subarachnoid hemorrhage: a prospective observational study
por: Emonds, Julian Josef, et al.
Publicado: (2023)

Gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and cardiovascular risk in patients with suspected functionally relevant coronary artery disease (fCAD)
por: Amrein, Melissa, et al.
Publicado: (2022)

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
por: Vogt, Nicholas M., et al.
Publicado: (2018)

Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis
por: Chen, Lu, et al.
Publicado: (2020)

Trimethylamine n-Oxide (TMAO) Modulates the Expression of Cardiovascular Disease-Related microRNAs and Their Targets
por: Díez-Ricote, Laura, et al.
Publicado: (2021)

Temporal Course of Plasma Trimethylamine N-Oxide (TMAO) Levels in ST-Elevation Myocardial Infarction
por: Almesned, Mohammad A., et al.
Publicado: (2021)

Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds
por: Ilyas, Ashal, et al.
Publicado: (2022)

The Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies
por: Huang, Rui, et al.
Publicado: (2021)

The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases
por: Zhen, Jing, et al.
Publicado: (2023)

Probiotic Therapy to Attenuate Weight Gain and Trimethylamine N-oxide (TMAO) Generation: A Cautionary Tale
por: Tang, W. H. Wilson, et al.
Publicado: (2015)

Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide
por: Savi, Monia, et al.
Publicado: (2018)

A New Light on Vitamin D in Obesity: A Novel Association with Trimethylamine-N-Oxide (TMAO)
por: Barrea, Luigi, et al.
Publicado: (2019)

Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis
por: Zhou, Dengcheng, et al.
Publicado: (2022)

Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection
por: Haissman, Judith M., et al.
Publicado: (2017)

A genome-wide systems analysis reveals strong link between colorectal cancer and trimethylamine N-oxide (TMAO), a gut microbial metabolite of dietary meat and fat
por: Xu, Rong, et al.
Publicado: (2015)

Trimethylamine N-Oxide (TMAO) Impairs Purinergic Induced Intracellular Calcium Increase and Nitric Oxide Release in Endothelial Cells
por: Querio, Giulia, et al.
Publicado: (2022)

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
por: Wang, BingYu, et al.
Publicado: (2021)

Marked elevation in plasma trimethylamine-N-oxide (TMAO) in patients with mitochondrial disorders treated with oral l-carnitine
por: Vallance, H.D., et al.
Publicado: (2018)

Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)
por: Gessner, A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a729ra2vteab01842dpqd8papo