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Impact of Maternal Weight Gain on the Newborn Metabolome

Pre-pregnancy obesity and excessive gestational weight gain (GWG) appear to affect birth weight and the offspring’s risk of obesity and disease later in life. However, the identification of the mediators of this relationship, could be of clinical interest, taking into account the presence of other c...

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Autores principales: Guixeres-Esteve, Teresa, Ponce-Zanón, Francisco, Morales, José Manuel, Lurbe, Empar, Alvarez-Pitti, Julio, Monleón, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142613/
https://www.ncbi.nlm.nih.gov/pubmed/37110219
http://dx.doi.org/10.3390/metabo13040561
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author Guixeres-Esteve, Teresa
Ponce-Zanón, Francisco
Morales, José Manuel
Lurbe, Empar
Alvarez-Pitti, Julio
Monleón, Daniel
author_facet Guixeres-Esteve, Teresa
Ponce-Zanón, Francisco
Morales, José Manuel
Lurbe, Empar
Alvarez-Pitti, Julio
Monleón, Daniel
author_sort Guixeres-Esteve, Teresa
collection PubMed
description Pre-pregnancy obesity and excessive gestational weight gain (GWG) appear to affect birth weight and the offspring’s risk of obesity and disease later in life. However, the identification of the mediators of this relationship, could be of clinical interest, taking into account the presence of other confounding factors, such as genetics and other shared influences. The aim of this study was to evaluate the metabolomic profiles of infants at birth (cord blood) and 6 and 12 months after birth to identify offspring metabolites associated with maternal GWG. Nuclear Magnetic Resonance (NMR) metabolic profiles were measured in 154 plasma samples from newborns (82 cord blood samples) and in 46 and 26 of these samples at 6 months and 12 months of age, respectively. The levels of relative abundance of 73 metabolomic parameters were determined in all the samples. We performed univariate and machine-learning analysis of the association between the metabolic levels and maternal weight gain adjusted for mother‘s age, Body Mass Index (BMI), diabetes, diet adherence and infant sex. Overall, our results showed differences, both at the univariate level and in the machine-learning models, between the offspring, according to the tertiles of maternal weight gain. Some of these differences were resolved at 6 and 12 months of age, whereas some others remained. Lactate and leucine were the metabolites with the strongest and longest association with maternal weight gain during pregnancy. Leucine, as well as other significant metabolites, have been associated in the past with metabolic wellness in both general and obese populations. Our results suggest that the metabolic changes associated to excessive GWG are present in children from early life.
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spelling pubmed-101426132023-04-29 Impact of Maternal Weight Gain on the Newborn Metabolome Guixeres-Esteve, Teresa Ponce-Zanón, Francisco Morales, José Manuel Lurbe, Empar Alvarez-Pitti, Julio Monleón, Daniel Metabolites Article Pre-pregnancy obesity and excessive gestational weight gain (GWG) appear to affect birth weight and the offspring’s risk of obesity and disease later in life. However, the identification of the mediators of this relationship, could be of clinical interest, taking into account the presence of other confounding factors, such as genetics and other shared influences. The aim of this study was to evaluate the metabolomic profiles of infants at birth (cord blood) and 6 and 12 months after birth to identify offspring metabolites associated with maternal GWG. Nuclear Magnetic Resonance (NMR) metabolic profiles were measured in 154 plasma samples from newborns (82 cord blood samples) and in 46 and 26 of these samples at 6 months and 12 months of age, respectively. The levels of relative abundance of 73 metabolomic parameters were determined in all the samples. We performed univariate and machine-learning analysis of the association between the metabolic levels and maternal weight gain adjusted for mother‘s age, Body Mass Index (BMI), diabetes, diet adherence and infant sex. Overall, our results showed differences, both at the univariate level and in the machine-learning models, between the offspring, according to the tertiles of maternal weight gain. Some of these differences were resolved at 6 and 12 months of age, whereas some others remained. Lactate and leucine were the metabolites with the strongest and longest association with maternal weight gain during pregnancy. Leucine, as well as other significant metabolites, have been associated in the past with metabolic wellness in both general and obese populations. Our results suggest that the metabolic changes associated to excessive GWG are present in children from early life. MDPI 2023-04-15 /pmc/articles/PMC10142613/ /pubmed/37110219 http://dx.doi.org/10.3390/metabo13040561 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guixeres-Esteve, Teresa
Ponce-Zanón, Francisco
Morales, José Manuel
Lurbe, Empar
Alvarez-Pitti, Julio
Monleón, Daniel
Impact of Maternal Weight Gain on the Newborn Metabolome
title Impact of Maternal Weight Gain on the Newborn Metabolome
title_full Impact of Maternal Weight Gain on the Newborn Metabolome
title_fullStr Impact of Maternal Weight Gain on the Newborn Metabolome
title_full_unstemmed Impact of Maternal Weight Gain on the Newborn Metabolome
title_short Impact of Maternal Weight Gain on the Newborn Metabolome
title_sort impact of maternal weight gain on the newborn metabolome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142613/
https://www.ncbi.nlm.nih.gov/pubmed/37110219
http://dx.doi.org/10.3390/metabo13040561
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