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CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders
Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically generated during the splicing of precursor RNAs. CircRN...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142617/ https://www.ncbi.nlm.nih.gov/pubmed/37104005 http://dx.doi.org/10.3390/ncrna9020023 |
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author | Ikeda, Yuka Morikawa, Sae Nakashima, Moeka Yoshikawa, Sayuri Taniguchi, Kurumi Sawamura, Haruka Suga, Naoko Tsuji, Ai Matsuda, Satoru |
author_facet | Ikeda, Yuka Morikawa, Sae Nakashima, Moeka Yoshikawa, Sayuri Taniguchi, Kurumi Sawamura, Haruka Suga, Naoko Tsuji, Ai Matsuda, Satoru |
author_sort | Ikeda, Yuka |
collection | PubMed |
description | Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically generated during the splicing of precursor RNAs. CircRNAs are key post-transcriptional and post-translational regulators of gene expression programs that might influence cellular response and/or function. In particular, circRNAs have been considered to function as sponges of specific miRNA, regulating cellular processes at the post-transcription stage. Accumulating evidence has shown that the aberrant expression of circRNAs could play a key role in the pathogenesis of several diseases. Notably, circRNAs, microRNAs, and several RNA-binding proteins, including the antiproliferative (APRO) family proteins, could be indispensable gene modulators, which might be strongly linked to the occurrence of diseases. In addition, circRNAs have attracted general interest for their stability, abundance in the brain, and their capability to cross the blood–brain barrier. Here, we present the current findings and theragnostic potentials of circRNAs in several diseases. With this, we aim to provide new insights to support the development of novel diagnostic and/or therapeutic strategies for these diseases. |
format | Online Article Text |
id | pubmed-10142617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101426172023-04-29 CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders Ikeda, Yuka Morikawa, Sae Nakashima, Moeka Yoshikawa, Sayuri Taniguchi, Kurumi Sawamura, Haruka Suga, Naoko Tsuji, Ai Matsuda, Satoru Noncoding RNA Review Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically generated during the splicing of precursor RNAs. CircRNAs are key post-transcriptional and post-translational regulators of gene expression programs that might influence cellular response and/or function. In particular, circRNAs have been considered to function as sponges of specific miRNA, regulating cellular processes at the post-transcription stage. Accumulating evidence has shown that the aberrant expression of circRNAs could play a key role in the pathogenesis of several diseases. Notably, circRNAs, microRNAs, and several RNA-binding proteins, including the antiproliferative (APRO) family proteins, could be indispensable gene modulators, which might be strongly linked to the occurrence of diseases. In addition, circRNAs have attracted general interest for their stability, abundance in the brain, and their capability to cross the blood–brain barrier. Here, we present the current findings and theragnostic potentials of circRNAs in several diseases. With this, we aim to provide new insights to support the development of novel diagnostic and/or therapeutic strategies for these diseases. MDPI 2023-03-31 /pmc/articles/PMC10142617/ /pubmed/37104005 http://dx.doi.org/10.3390/ncrna9020023 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ikeda, Yuka Morikawa, Sae Nakashima, Moeka Yoshikawa, Sayuri Taniguchi, Kurumi Sawamura, Haruka Suga, Naoko Tsuji, Ai Matsuda, Satoru CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders |
title | CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders |
title_full | CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders |
title_fullStr | CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders |
title_full_unstemmed | CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders |
title_short | CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders |
title_sort | circrnas and rna-binding proteins involved in the pathogenesis of cancers or central nervous system disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142617/ https://www.ncbi.nlm.nih.gov/pubmed/37104005 http://dx.doi.org/10.3390/ncrna9020023 |
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