Cargando…
First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn
Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sp...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142742/ https://www.ncbi.nlm.nih.gov/pubmed/37111393 http://dx.doi.org/10.3390/pathogens12040507 |
_version_ | 1785033686244130816 |
---|---|
author | Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumárraga, Martín J. de Waard, Jacobus H. |
author_facet | Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumárraga, Martín J. de Waard, Jacobus H. |
author_sort | Echeverria, Gustavo |
collection | PubMed |
description | Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it. |
format | Online Article Text |
id | pubmed-10142742 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101427422023-04-29 First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumárraga, Martín J. de Waard, Jacobus H. Pathogens Case Report Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it. MDPI 2023-03-23 /pmc/articles/PMC10142742/ /pubmed/37111393 http://dx.doi.org/10.3390/pathogens12040507 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Echeverria, Gustavo Rueda, Veronica Espinoza, Wilson Rosero, Carlos Zumárraga, Martín J. de Waard, Jacobus H. First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
title | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
title_full | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
title_fullStr | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
title_full_unstemmed | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
title_short | First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn |
title_sort | first case reports of nontuberculous mycobacterial (ntm) lung disease in ecuador: important lessons to learn |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142742/ https://www.ncbi.nlm.nih.gov/pubmed/37111393 http://dx.doi.org/10.3390/pathogens12040507 |
work_keys_str_mv | AT echeverriagustavo firstcasereportsofnontuberculousmycobacterialntmlungdiseaseinecuadorimportantlessonstolearn AT ruedaveronica firstcasereportsofnontuberculousmycobacterialntmlungdiseaseinecuadorimportantlessonstolearn AT espinozawilson firstcasereportsofnontuberculousmycobacterialntmlungdiseaseinecuadorimportantlessonstolearn AT roserocarlos firstcasereportsofnontuberculousmycobacterialntmlungdiseaseinecuadorimportantlessonstolearn AT zumarragamartinj firstcasereportsofnontuberculousmycobacterialntmlungdiseaseinecuadorimportantlessonstolearn AT dewaardjacobush firstcasereportsofnontuberculousmycobacterialntmlungdiseaseinecuadorimportantlessonstolearn |