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Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks

Lumpy skin disease virus (LSDV) is capable of causing transboundary diseases characterized by fever, nodules on the skin, mucous membranes, and inner organs. The disease may cause emaciation with the enlargement of lymph nodes and sometimes death. It has had endemic importance in various parts of As...

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Autores principales: Li, Yan, Zeng, Zhibo, Li, Kewei, Rehman, Mujeeb Ur, Nawaz, Shah, Kulyar, Muhammad Fakhar-e-Alam, Hu, Miao, Zhang, Wenqian, Zhang, Zhao, An, Miao, Hu, Jianwu, Li, Jiakui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142747/
https://www.ncbi.nlm.nih.gov/pubmed/37112860
http://dx.doi.org/10.3390/v15040880
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author Li, Yan
Zeng, Zhibo
Li, Kewei
Rehman, Mujeeb Ur
Nawaz, Shah
Kulyar, Muhammad Fakhar-e-Alam
Hu, Miao
Zhang, Wenqian
Zhang, Zhao
An, Miao
Hu, Jianwu
Li, Jiakui
author_facet Li, Yan
Zeng, Zhibo
Li, Kewei
Rehman, Mujeeb Ur
Nawaz, Shah
Kulyar, Muhammad Fakhar-e-Alam
Hu, Miao
Zhang, Wenqian
Zhang, Zhao
An, Miao
Hu, Jianwu
Li, Jiakui
author_sort Li, Yan
collection PubMed
description Lumpy skin disease virus (LSDV) is capable of causing transboundary diseases characterized by fever, nodules on the skin, mucous membranes, and inner organs. The disease may cause emaciation with the enlargement of lymph nodes and sometimes death. It has had endemic importance in various parts of Asia in recent years, causing substantial economic losses to the cattle industry. The current study reported a suspected LSDV infection (based on signs and symptoms) from a mixed farm of yak and cattle in Sichuan Province, China. The clinical samples were found positive for LSDV using qPCR and ELISA, while LSDV DNA was detected in Culex tritaeniorhynchus Giles. The complete genome sequence of China/LSDV/SiC/2021 was determined by Next-generation sequencing. It was found that China/LSDV/SiC/2021 is highly homologous to the novel vaccine-related recombinant LSDV currently emerging in China and countries surrounding China. Phylogenetic tree analysis revealed that the novel vaccine-associated recombinant LSDV formed a unique dendrograms topology between field and vaccine-associated strains. China/LSDV/SiC/2021 was found to be a novel recombinant strain, with at least 18 recombination events via field viruses identified in the genome sequence. These results suggest that recombinant LSDV can cause high mortality in yaks, and its transmission might be due to the Culex tritaeniorhynchus Giles, which acts as a mechanical vector.
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spelling pubmed-101427472023-04-29 Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks Li, Yan Zeng, Zhibo Li, Kewei Rehman, Mujeeb Ur Nawaz, Shah Kulyar, Muhammad Fakhar-e-Alam Hu, Miao Zhang, Wenqian Zhang, Zhao An, Miao Hu, Jianwu Li, Jiakui Viruses Communication Lumpy skin disease virus (LSDV) is capable of causing transboundary diseases characterized by fever, nodules on the skin, mucous membranes, and inner organs. The disease may cause emaciation with the enlargement of lymph nodes and sometimes death. It has had endemic importance in various parts of Asia in recent years, causing substantial economic losses to the cattle industry. The current study reported a suspected LSDV infection (based on signs and symptoms) from a mixed farm of yak and cattle in Sichuan Province, China. The clinical samples were found positive for LSDV using qPCR and ELISA, while LSDV DNA was detected in Culex tritaeniorhynchus Giles. The complete genome sequence of China/LSDV/SiC/2021 was determined by Next-generation sequencing. It was found that China/LSDV/SiC/2021 is highly homologous to the novel vaccine-related recombinant LSDV currently emerging in China and countries surrounding China. Phylogenetic tree analysis revealed that the novel vaccine-associated recombinant LSDV formed a unique dendrograms topology between field and vaccine-associated strains. China/LSDV/SiC/2021 was found to be a novel recombinant strain, with at least 18 recombination events via field viruses identified in the genome sequence. These results suggest that recombinant LSDV can cause high mortality in yaks, and its transmission might be due to the Culex tritaeniorhynchus Giles, which acts as a mechanical vector. MDPI 2023-03-29 /pmc/articles/PMC10142747/ /pubmed/37112860 http://dx.doi.org/10.3390/v15040880 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Li, Yan
Zeng, Zhibo
Li, Kewei
Rehman, Mujeeb Ur
Nawaz, Shah
Kulyar, Muhammad Fakhar-e-Alam
Hu, Miao
Zhang, Wenqian
Zhang, Zhao
An, Miao
Hu, Jianwu
Li, Jiakui
Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks
title Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks
title_full Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks
title_fullStr Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks
title_full_unstemmed Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks
title_short Detection of Culex tritaeniorhynchus Giles and Novel Recombinant Strain of Lumpy Skin Disease Virus Causes High Mortality in Yaks
title_sort detection of culex tritaeniorhynchus giles and novel recombinant strain of lumpy skin disease virus causes high mortality in yaks
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142747/
https://www.ncbi.nlm.nih.gov/pubmed/37112860
http://dx.doi.org/10.3390/v15040880
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