Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives

A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double b...

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Autores principales: Sun, Qianqian, Li, Hongxiao, Chen, Xingyu, Hao, Jian, Deng, Hongmei, Jiang, Haizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142801/
https://www.ncbi.nlm.nih.gov/pubmed/37110812
http://dx.doi.org/10.3390/molecules28083578
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author Sun, Qianqian
Li, Hongxiao
Chen, Xingyu
Hao, Jian
Deng, Hongmei
Jiang, Haizhen
author_facet Sun, Qianqian
Li, Hongxiao
Chen, Xingyu
Hao, Jian
Deng, Hongmei
Jiang, Haizhen
author_sort Sun, Qianqian
collection PubMed
description A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double bonds in 2-allyloxybenzaldehyde was an effective route to access a series of 3-aryldifluoromethyl-containing chroman-4-one derivatives in moderate to good yields under mild reaction conditions.
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spelling pubmed-101428012023-04-29 Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives Sun, Qianqian Li, Hongxiao Chen, Xingyu Hao, Jian Deng, Hongmei Jiang, Haizhen Molecules Article A convenient silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes has been developed. Experimental studies disclosed that the addition of aryldifluoromethyl radicals in situ produced from easily accessible gem-difluoroarylacetic acids to unactivated double bonds in 2-allyloxybenzaldehyde was an effective route to access a series of 3-aryldifluoromethyl-containing chroman-4-one derivatives in moderate to good yields under mild reaction conditions. MDPI 2023-04-19 /pmc/articles/PMC10142801/ /pubmed/37110812 http://dx.doi.org/10.3390/molecules28083578 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Qianqian
Li, Hongxiao
Chen, Xingyu
Hao, Jian
Deng, Hongmei
Jiang, Haizhen
Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
title Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
title_full Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
title_fullStr Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
title_full_unstemmed Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
title_short Silver-Promoted Radical Cascade Aryldifluoromethylation/Cyclization of 2-Allyloxybenzaldehydes for the Synthesis of 3-Aryldifluoromethyl-Containing Chroman-4-one Derivatives
title_sort silver-promoted radical cascade aryldifluoromethylation/cyclization of 2-allyloxybenzaldehydes for the synthesis of 3-aryldifluoromethyl-containing chroman-4-one derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142801/
https://www.ncbi.nlm.nih.gov/pubmed/37110812
http://dx.doi.org/10.3390/molecules28083578
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