Single-cell sequencing reveals the immune microenvironment landscape related to anti-PD-1 resistance in metastatic colorectal cancer with high microsatellite instability

BACKGROUND: The objective response rate of microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) patients with first-line anti-programmed cell death protein-1 (PD-1) monotherapy is only 40–45%. Single-cell RNA sequencing (scRNA-seq) enables unbiased analysis of the full variety...

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Detalles Bibliográficos
Autores principales: Wu, Tao, Zhang, Xuan, Liu, Xinxing, Cai, Xinyi, Shen, Tao, Pan, Dingguo, Liang, Rui, Ding, Rong, Hu, Ruixi, Dong, Jianhua, Li, Furong, Li, Jinsha, Xie, Lin, Wang, Chunlong, Geng, Shilei, Yang, Zhaoyu, Xing, Lu, Li, YunFeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142806/
https://www.ncbi.nlm.nih.gov/pubmed/37106440
http://dx.doi.org/10.1186/s12916-023-02866-y

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