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Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes

We hypothesize that different routes of administration may lead to altered pharmacokinetics/pharmacodynamics (PK/PD) behavior of antibody-drug conjugates (ADCs) and may help to improve their therapeutic index. To evaluate this hypothesis, here we performed PK/PD evaluation for an ADC administered vi...

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Detalles Bibliográficos
Autores principales:	Chang, Hsuan-Ping, Le, Huyen Khanh, Shah, Dhaval K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10142912/ https://www.ncbi.nlm.nih.gov/pubmed/37111619 http://dx.doi.org/10.3390/pharmaceutics15041132

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