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Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study
The widespread dispersion of pigs infected with cysticercosis across endemic villages, low cyst burden among infected pigs, and low prevalence of taeniasis all suggest that pig ingestion of human feces is not the only mode of transmission for Taenia solium. Our objective was to evaluate the risk of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143142/ https://www.ncbi.nlm.nih.gov/pubmed/37111483 http://dx.doi.org/10.3390/pathogens12040597 |
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author | Gonzales-Gustavson, Eloy Pray, Ian W. Gamboa, Ricardo Muro, Claudio Vilchez, Percy Gomez-Puerta, Luis Vargas-Calla, Ana Bonnet, Gabrielle Pizzitutti, Francesco Garcia, Hector H. Gonzalez, Armando E. O’Neal, Seth E. |
author_facet | Gonzales-Gustavson, Eloy Pray, Ian W. Gamboa, Ricardo Muro, Claudio Vilchez, Percy Gomez-Puerta, Luis Vargas-Calla, Ana Bonnet, Gabrielle Pizzitutti, Francesco Garcia, Hector H. Gonzalez, Armando E. O’Neal, Seth E. |
author_sort | Gonzales-Gustavson, Eloy |
collection | PubMed |
description | The widespread dispersion of pigs infected with cysticercosis across endemic villages, low cyst burden among infected pigs, and low prevalence of taeniasis all suggest that pig ingestion of human feces is not the only mode of transmission for Taenia solium. Our objective was to evaluate the risk of porcine cysticercosis associated with exposure to human feces, dung beetles, and flies in an endemic community setting. We used a cluster-randomized cohort design to compare the risk of developing antibodies and infection among 120 piglets raised in either free-roaming (FR), standard corral (SC), or netted corral environments (NC). We collected monthly blood samples to detect serum antibodies and necropsied all pigs after 10 months to identify cysts. A total of 66 piglets developed antibodies with the relative risk of seropositivity in FR vs. all corralled pigs increasing significantly after 18 weeks. Of 108 necropsied pigs, 15 had T. solium cysts, all belonging to the FR group. Corrals were protective against infection but less so against seropositivity. NC, which did not completely exclude insects, did not provide added protection against seropositivity as compared to SC. The results of this study suggest that dung beetles and flies do not play an important role in infection. |
format | Online Article Text |
id | pubmed-10143142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101431422023-04-29 Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study Gonzales-Gustavson, Eloy Pray, Ian W. Gamboa, Ricardo Muro, Claudio Vilchez, Percy Gomez-Puerta, Luis Vargas-Calla, Ana Bonnet, Gabrielle Pizzitutti, Francesco Garcia, Hector H. Gonzalez, Armando E. O’Neal, Seth E. Pathogens Article The widespread dispersion of pigs infected with cysticercosis across endemic villages, low cyst burden among infected pigs, and low prevalence of taeniasis all suggest that pig ingestion of human feces is not the only mode of transmission for Taenia solium. Our objective was to evaluate the risk of porcine cysticercosis associated with exposure to human feces, dung beetles, and flies in an endemic community setting. We used a cluster-randomized cohort design to compare the risk of developing antibodies and infection among 120 piglets raised in either free-roaming (FR), standard corral (SC), or netted corral environments (NC). We collected monthly blood samples to detect serum antibodies and necropsied all pigs after 10 months to identify cysts. A total of 66 piglets developed antibodies with the relative risk of seropositivity in FR vs. all corralled pigs increasing significantly after 18 weeks. Of 108 necropsied pigs, 15 had T. solium cysts, all belonging to the FR group. Corrals were protective against infection but less so against seropositivity. NC, which did not completely exclude insects, did not provide added protection against seropositivity as compared to SC. The results of this study suggest that dung beetles and flies do not play an important role in infection. MDPI 2023-04-14 /pmc/articles/PMC10143142/ /pubmed/37111483 http://dx.doi.org/10.3390/pathogens12040597 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gonzales-Gustavson, Eloy Pray, Ian W. Gamboa, Ricardo Muro, Claudio Vilchez, Percy Gomez-Puerta, Luis Vargas-Calla, Ana Bonnet, Gabrielle Pizzitutti, Francesco Garcia, Hector H. Gonzalez, Armando E. O’Neal, Seth E. Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study |
title | Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study |
title_full | Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study |
title_fullStr | Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study |
title_full_unstemmed | Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study |
title_short | Evaluating the Role of Corrals and Insects in the Transmission of Porcine Cysticercosis: A Cohort Study |
title_sort | evaluating the role of corrals and insects in the transmission of porcine cysticercosis: a cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143142/ https://www.ncbi.nlm.nih.gov/pubmed/37111483 http://dx.doi.org/10.3390/pathogens12040597 |
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