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Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea

The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case–control study using data from the Korean N...

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Autores principales: Kwon, Mi Jung, Lee, Jung Woo, Kang, Ho Suk, Lim, Hyun, Kim, Eun Soo, Kim, Nan Young, Choi, Hyo Geun, Kim, Min-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143191/
https://www.ncbi.nlm.nih.gov/pubmed/37111293
http://dx.doi.org/10.3390/ph16040536
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author Kwon, Mi Jung
Lee, Jung Woo
Kang, Ho Suk
Lim, Hyun
Kim, Eun Soo
Kim, Nan Young
Choi, Hyo Geun
Kim, Min-Jeong
author_facet Kwon, Mi Jung
Lee, Jung Woo
Kang, Ho Suk
Lim, Hyun
Kim, Eun Soo
Kim, Nan Young
Choi, Hyo Geun
Kim, Min-Jeong
author_sort Kwon, Mi Jung
collection PubMed
description The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case–control study using data from the Korean National Health Insurance Service Health Screening Cohort (2002–2019) to determine the likelihood of gallstone disease according to periods of previous statin use and type of statin. Among the 514,866 participants, 22,636 diagnosed with gallstones at ≥2 clinic visits (using the International Classification of Diseases, 10th revision, code K80) were matched 1:4 to 90,544 controls for age, sex, income, and residential area, and their statin prescription history for 2 years prior to the index date was examined. Propensity-score-weighted odds ratios (ORs) for gallstone disease were calculated using conditional logistic regression. Long-term use (>545 days) of any statin or lipophilic statins was associated with lower odds of incident gallstones (OR = 0.91, 95% confidence interval [CI] = 0.86–0.96, p < 0.001 and OR = 0.88, 95% CI = 0.83–0.93, p < 0.001, respectively) after adjusting for confounders. Short-term use (180–545 days) of any statin or hydrophilic statins was not statistically related to incident gallstones. In summary, prior statin medication, particularly long-term lipophilic statin use, may confer a preventive advantage against gallstone disease.
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spelling pubmed-101431912023-04-29 Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea Kwon, Mi Jung Lee, Jung Woo Kang, Ho Suk Lim, Hyun Kim, Eun Soo Kim, Nan Young Choi, Hyo Geun Kim, Min-Jeong Pharmaceuticals (Basel) Article The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case–control study using data from the Korean National Health Insurance Service Health Screening Cohort (2002–2019) to determine the likelihood of gallstone disease according to periods of previous statin use and type of statin. Among the 514,866 participants, 22,636 diagnosed with gallstones at ≥2 clinic visits (using the International Classification of Diseases, 10th revision, code K80) were matched 1:4 to 90,544 controls for age, sex, income, and residential area, and their statin prescription history for 2 years prior to the index date was examined. Propensity-score-weighted odds ratios (ORs) for gallstone disease were calculated using conditional logistic regression. Long-term use (>545 days) of any statin or lipophilic statins was associated with lower odds of incident gallstones (OR = 0.91, 95% confidence interval [CI] = 0.86–0.96, p < 0.001 and OR = 0.88, 95% CI = 0.83–0.93, p < 0.001, respectively) after adjusting for confounders. Short-term use (180–545 days) of any statin or hydrophilic statins was not statistically related to incident gallstones. In summary, prior statin medication, particularly long-term lipophilic statin use, may confer a preventive advantage against gallstone disease. MDPI 2023-04-03 /pmc/articles/PMC10143191/ /pubmed/37111293 http://dx.doi.org/10.3390/ph16040536 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kwon, Mi Jung
Lee, Jung Woo
Kang, Ho Suk
Lim, Hyun
Kim, Eun Soo
Kim, Nan Young
Choi, Hyo Geun
Kim, Min-Jeong
Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
title Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
title_full Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
title_fullStr Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
title_full_unstemmed Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
title_short Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
title_sort association between gallstone disease and statin use: a nested case—control study in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143191/
https://www.ncbi.nlm.nih.gov/pubmed/37111293
http://dx.doi.org/10.3390/ph16040536
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