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Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas

Maspin is an important biomarker which was proven to be correlated to many pathological features that can help the oncologists, the surgeons and also the pathologists for choosing the personalized treatment of the patients. Maspin expression correlates with the budding of colorectal adenocarcinomas...

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Autores principales: Bratei, Alexandru Adrian, Stefan-van Staden, Raluca-Ioana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143283/
https://www.ncbi.nlm.nih.gov/pubmed/37109589
http://dx.doi.org/10.3390/life13041060
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author Bratei, Alexandru Adrian
Stefan-van Staden, Raluca-Ioana
author_facet Bratei, Alexandru Adrian
Stefan-van Staden, Raluca-Ioana
author_sort Bratei, Alexandru Adrian
collection PubMed
description Maspin is an important biomarker which was proven to be correlated to many pathological features that can help the oncologists, the surgeons and also the pathologists for choosing the personalized treatment of the patients. Maspin expression correlates with the budding of colorectal adenocarcinomas that is usually used mostly in immunohistochemistry. In this preliminary study, a small number of patients with clinical and pathological features were selected. Four kinds of samples (tumoral tissues, blood, saliva and urine) were analyzed using a stochastic method using stochastic microsensors. Whole blood maspin concentration values were related to budding, molecular subtype and location. Tissular maspin concentrations were related to location, maxi-mum diameter and pN value from TNM staging system. Salivary maspin concentrations were related to budding, mucinous compound and macroscopic features. Urinary maspin concentrations were related to pT value from TNM staging system, budding and molecular subtype. The correlations made in this paper may be used for fast diagnostic of colorectal adenocarcinomas, after which, it will be tested on a significant number of patients confirmed with colon cancer, in different stages of evolution.
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spelling pubmed-101432832023-04-29 Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas Bratei, Alexandru Adrian Stefan-van Staden, Raluca-Ioana Life (Basel) Article Maspin is an important biomarker which was proven to be correlated to many pathological features that can help the oncologists, the surgeons and also the pathologists for choosing the personalized treatment of the patients. Maspin expression correlates with the budding of colorectal adenocarcinomas that is usually used mostly in immunohistochemistry. In this preliminary study, a small number of patients with clinical and pathological features were selected. Four kinds of samples (tumoral tissues, blood, saliva and urine) were analyzed using a stochastic method using stochastic microsensors. Whole blood maspin concentration values were related to budding, molecular subtype and location. Tissular maspin concentrations were related to location, maxi-mum diameter and pN value from TNM staging system. Salivary maspin concentrations were related to budding, mucinous compound and macroscopic features. Urinary maspin concentrations were related to pT value from TNM staging system, budding and molecular subtype. The correlations made in this paper may be used for fast diagnostic of colorectal adenocarcinomas, after which, it will be tested on a significant number of patients confirmed with colon cancer, in different stages of evolution. MDPI 2023-04-20 /pmc/articles/PMC10143283/ /pubmed/37109589 http://dx.doi.org/10.3390/life13041060 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bratei, Alexandru Adrian
Stefan-van Staden, Raluca-Ioana
Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas
title Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas
title_full Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas
title_fullStr Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas
title_full_unstemmed Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas
title_short Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas
title_sort correlation between maspin levels in different biological samples and pathologic features in colorectal adenocarcinomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143283/
https://www.ncbi.nlm.nih.gov/pubmed/37109589
http://dx.doi.org/10.3390/life13041060
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