Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai

Seven new lobane diterpenoids, namely, lobocatalens A–G (1–7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. A...

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Detalles Bibliográficos
Autores principales: Zhang, Jiarui, Ma, Huixue, Jin, Shuangshuang, Liu, Xuehuan, Li, Lei, Liu, Zhaonan, Li, Guoqiang, Li, Pinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143306/
https://www.ncbi.nlm.nih.gov/pubmed/37103362
http://dx.doi.org/10.3390/md21040223
Descripción
Sumario:Seven new lobane diterpenoids, namely, lobocatalens A–G (1–7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.

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