Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai

Seven new lobane diterpenoids, namely, lobocatalens A–G (1–7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. A...

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Autores principales: Zhang, Jiarui, Ma, Huixue, Jin, Shuangshuang, Liu, Xuehuan, Li, Lei, Liu, Zhaonan, Li, Guoqiang, Li, Pinglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143306/
https://www.ncbi.nlm.nih.gov/pubmed/37103362
http://dx.doi.org/10.3390/md21040223
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author Zhang, Jiarui
Ma, Huixue
Jin, Shuangshuang
Liu, Xuehuan
Li, Lei
Liu, Zhaonan
Li, Guoqiang
Li, Pinglin
author_facet Zhang, Jiarui
Ma, Huixue
Jin, Shuangshuang
Liu, Xuehuan
Li, Lei
Liu, Zhaonan
Li, Guoqiang
Li, Pinglin
author_sort Zhang, Jiarui
collection PubMed
description Seven new lobane diterpenoids, namely, lobocatalens A–G (1–7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.
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spelling pubmed-101433062023-04-29 Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai Zhang, Jiarui Ma, Huixue Jin, Shuangshuang Liu, Xuehuan Li, Lei Liu, Zhaonan Li, Guoqiang Li, Pinglin Mar Drugs Article Seven new lobane diterpenoids, namely, lobocatalens A–G (1–7), were isolated from the Xisha soft coral Lobophytum catalai. Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A (1) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line. MDPI 2023-03-30 /pmc/articles/PMC10143306/ /pubmed/37103362 http://dx.doi.org/10.3390/md21040223 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Jiarui
Ma, Huixue
Jin, Shuangshuang
Liu, Xuehuan
Li, Lei
Liu, Zhaonan
Li, Guoqiang
Li, Pinglin
Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai
title Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai
title_full Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai
title_fullStr Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai
title_full_unstemmed Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai
title_short Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai
title_sort seven new lobane diterpenoids from the soft coral lobophytum catalai
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143306/
https://www.ncbi.nlm.nih.gov/pubmed/37103362
http://dx.doi.org/10.3390/md21040223
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