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The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth
Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled growth and spread of abnormal cells. While cancer can be challenging and life-altering, advances in research and development have led to the identification of new promising anti-cancer targets. Telomerase is one...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143453/ https://www.ncbi.nlm.nih.gov/pubmed/37111362 http://dx.doi.org/10.3390/ph16040605 |
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author | Parekh, Neel Garg, Ashish Choudhary, Renuka Gupta, Madhu Kaur, Ginpreet Ramniwas, Seema Shahwan, Moyad Tuli, Hardeep Singh Sethi, Gautam |
author_facet | Parekh, Neel Garg, Ashish Choudhary, Renuka Gupta, Madhu Kaur, Ginpreet Ramniwas, Seema Shahwan, Moyad Tuli, Hardeep Singh Sethi, Gautam |
author_sort | Parekh, Neel |
collection | PubMed |
description | Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled growth and spread of abnormal cells. While cancer can be challenging and life-altering, advances in research and development have led to the identification of new promising anti-cancer targets. Telomerase is one such target that is overexpressed in almost all cancer cells and plays a critical role in maintaining telomere length, which is essential for cell proliferation and survival. Inhibiting telomerase activity can lead to telomere shortening and eventual cell death, thus presenting itself as a potential target for cancer therapy. Naturally occurring flavonoids are a class of compounds that have already been shown to possess different biological properties, including the anti-cancer property. They are present in various everyday food sources and richly present in fruits, nuts, soybeans, vegetables, tea, wine, and berries, to name a few. Thus, these flavonoids could inhibit or deactivate telomerase expression in cancer cells by different mechanisms, which include inhibiting the expression of hTERT, mRNA, protein, and nuclear translocation, inhibiting the binding of transcription factors to hTERT promoters, and even telomere shortening. Numerous cell line studies and in vivo experiments have supported this hypothesis, and this development could serve as a vital and innovative therapeutic option for cancer. In this light, we aim to elucidate the role of telomerase as a potential anti-cancer target. Subsequently, we have illustrated that how commonly found natural flavonoids demonstrate their anti-cancer activity via telomerase inactivation in different cancer types, thus proving the potential of these naturally occurring flavonoids as useful therapeutic agents. |
format | Online Article Text |
id | pubmed-10143453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-101434532023-04-29 The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth Parekh, Neel Garg, Ashish Choudhary, Renuka Gupta, Madhu Kaur, Ginpreet Ramniwas, Seema Shahwan, Moyad Tuli, Hardeep Singh Sethi, Gautam Pharmaceuticals (Basel) Review Cancer is a complex and multifaceted group of diseases characterized by the uncontrolled growth and spread of abnormal cells. While cancer can be challenging and life-altering, advances in research and development have led to the identification of new promising anti-cancer targets. Telomerase is one such target that is overexpressed in almost all cancer cells and plays a critical role in maintaining telomere length, which is essential for cell proliferation and survival. Inhibiting telomerase activity can lead to telomere shortening and eventual cell death, thus presenting itself as a potential target for cancer therapy. Naturally occurring flavonoids are a class of compounds that have already been shown to possess different biological properties, including the anti-cancer property. They are present in various everyday food sources and richly present in fruits, nuts, soybeans, vegetables, tea, wine, and berries, to name a few. Thus, these flavonoids could inhibit or deactivate telomerase expression in cancer cells by different mechanisms, which include inhibiting the expression of hTERT, mRNA, protein, and nuclear translocation, inhibiting the binding of transcription factors to hTERT promoters, and even telomere shortening. Numerous cell line studies and in vivo experiments have supported this hypothesis, and this development could serve as a vital and innovative therapeutic option for cancer. In this light, we aim to elucidate the role of telomerase as a potential anti-cancer target. Subsequently, we have illustrated that how commonly found natural flavonoids demonstrate their anti-cancer activity via telomerase inactivation in different cancer types, thus proving the potential of these naturally occurring flavonoids as useful therapeutic agents. MDPI 2023-04-17 /pmc/articles/PMC10143453/ /pubmed/37111362 http://dx.doi.org/10.3390/ph16040605 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Parekh, Neel Garg, Ashish Choudhary, Renuka Gupta, Madhu Kaur, Ginpreet Ramniwas, Seema Shahwan, Moyad Tuli, Hardeep Singh Sethi, Gautam The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth |
title | The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth |
title_full | The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth |
title_fullStr | The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth |
title_full_unstemmed | The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth |
title_short | The Role of Natural Flavonoids as Telomerase Inhibitors in Suppressing Cancer Growth |
title_sort | role of natural flavonoids as telomerase inhibitors in suppressing cancer growth |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10143453/ https://www.ncbi.nlm.nih.gov/pubmed/37111362 http://dx.doi.org/10.3390/ph16040605 |
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